Exploring targets in oropharyngeal cancer – association with immune markers and AI-scoring of B7-H3 expression

Jacklyn Liu; Helen Bewicke-Copley; Shruti Patel; Oscar Emanuel; Nicholas Counsell; Shachi J. Sharma; Volker Schartinger; Oliver Siefer; Ulrike Wieland; Nora Würdemann; Rocio Garcia-Marin; Jozsef Dudas; Dominic Patel; David Allen; Naomi Guppy; Josep Linares; Adriana Resende-Alves; David J. Howard; Liam Masterson; Francis M. Vaz; Paul O’Flynn; Cillian T. Forde; Luke Williams; Umar Rehman; John A. Hartley; Johannes Haybaeck; Herbert Riechelmann; Amrita Jay; Tim R. Fenton; Martin D. Forster; Oluyori Adegun; Kerry Chester; Jackie McDermott; Ann Sandison; Manuel Rodriguez Justo; Juan P. Rodrigo; Mario Hermsen John A. Tadross; Jens P. Klussmann; Matt Lechner

doi:10.1002/ctm2.70265

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) :e70265 DOI: 10.1002/ctm2.70265

LETTER TO THE JOURNAL

Exploring targets in oropharyngeal cancer – association with immune markers and AI-scoring of B7-H3 expression

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¹. UCL Division of Surgery and Interventional Sciences, London, UK

². UCL Cancer Institute, London, UK

³. Head and Neck Surgery, Cancer Research UK and UCL Cancer Trials Centre, London, United Kingdom

⁴. Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany

⁵. Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany

⁶. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

⁷. Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria

⁸. Institute of Virology, National Reference Center for Papilloma and Polyomaviruses, University of Cologne, Oviedo, Germany

⁹. Department of Head and Neck Oncology, Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncología Del Principado de Asturias (IUOPA), Centro de Investigación Biomédica en Red (CIBER-ONC), Oviedo, Spain

¹⁰. Department of Histopathology, University College London Hospitals NHS Foundation Trust, London, UK

¹¹. HSL Advanced Diagnostics, HSL Advanced Diagnostics, London, UK

¹². Breast Cancer Now Research Centre, The Institute of Cancer Research, London, UK

¹³. ENT Department, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK

¹⁴. Royal National Throat, Nose and Ear Hospital and Head and Neck Centre, London, UK

¹⁵. Department of ENT, Cambridge University Hospitals NHS Trust, Cambridge, UK

¹⁶. Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria

¹⁷. Diagnostic & Research Center for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, Graz, Austria

¹⁸. Faculty of Medicine, School of Cancer Sciences, Cancer Research UK Centre, University of Southampton, Southampton, UK

¹⁹. Department of Histopathology, Imperial College Healthcare NHS Trust, London, UK

²⁰. Department of Histopathology, Guys and St. Thomas’ NHS Trust, London, UK

²¹. Department of Histopathology and East Midlands & East of England Genomic Laboratory Hub, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

²². MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK

m.lechner@ucl.ac.uk

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Jacklyn Liu, Helen Bewicke-Copley, Shruti Patel, Oscar Emanuel, Nicholas Counsell, Shachi J. Sharma, Volker Schartinger, Oliver Siefer, Ulrike Wieland, Nora Würdemann, Rocio Garcia-Marin, Jozsef Dudas, Dominic Patel, David Allen, Naomi Guppy, Josep Linares, Adriana Resende-Alves, David J. Howard, Liam Masterson, Francis M. Vaz, Paul O’Flynn, Cillian T. Forde, Luke Williams, Umar Rehman, John A. Hartley, Johannes Haybaeck, Herbert Riechelmann, Amrita Jay, Tim R. Fenton, Martin D. Forster, Oluyori Adegun, Kerry Chester, Jackie McDermott, Ann Sandison, Manuel Rodriguez Justo, Juan P. Rodrigo, Mario Hermsen John A. Tadross, Jens P. Klussmann, Matt Lechner. Exploring targets in oropharyngeal cancer – association with immune markers and AI-scoring of B7-H3 expression. Clinical and Translational Medicine, 2025, 15(3): e70265 DOI:10.1002/ctm2.70265

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References

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.