Mechanisms of SOSS-Integrator–PP2A complex in attenuating R-loops and promoting genome stability

References

[1] Adelman K, Lis JT. Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet. 2012;13(10):720-731.

[2] Zheng H, Qi Y, Hu S, et al. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science. 2020;370(6520):eabb5872.

[3] Huang KL, Jee D, Stein CB, et al. Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination. Mol Cell. 2020;80(2):345-358.e9.

[4] Vervoort SJ, Welsh SA, Devlin JR, et al. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Cell. 2021;184(12):3143-3162.e32.

[5] Niehrs C, Luke B. Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol. 2020;21(3):167-178.

[6] Xu C, Li C, Chen J, et al. R-loop-dependent promoter-proximal termination ensures genome stability. Nature. 2023;621(7979):610-619.

[7] Crossley MP, Song C, Bocek MJ, et al. R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response. Nature. 2023;613(7942):187-194.

[8] Petermann E, Lan L, Zou L. Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids. Nat Rev Mol Cell Biol. 2022;23(8):521-540.

[9] Groelly FJ, Fawkes M, Dagg RA, Blackford AN, Tarsounas M. Targeting DNA damage response pathways in cancer. Nat Rev Cancer. 2023;23(2):78-94.

[10] Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372(26):2509-2520.

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