Single-cell RNA sequencing gene signatures for classifying and scoring exhausted CD8+ T cells in B-cell acute lymphoblastic leukaemia

Songnan Sui; Yun Tian; Xiaofang Wang; Chengwu Zeng; Oscar Junhong Luo; Yangqiu Li

doi:10.1111/cpr.13583

Cell Proliferation ›› 2024, Vol. 57 ›› Issue (3) :e13583 DOI: 10.1111/cpr.13583

LETTER TO THE EDITOR

Single-cell RNA sequencing gene signatures for classifying and scoring exhausted CD8⁺ T cells in B-cell acute lymphoblastic leukaemia

Songnan Sui ¹^,²^,³
, Yun Tian ¹^,²^,³
, Xiaofang Wang ⁴
, Chengwu Zeng ¹
, Oscar Junhong Luo ³^,^†
, Yangqiu Li ¹^,²^,^†

Author information +

History +

PDF

Cite this article

Download citation ▾

Songnan Sui, Yun Tian, Xiaofang Wang, Chengwu Zeng, Oscar Junhong Luo, Yangqiu Li. Single-cell RNA sequencing gene signatures for classifying and scoring exhausted CD8⁺ T cells in B-cell acute lymphoblastic leukaemia. Cell Proliferation, 2024, 57(3): e13583 DOI:10.1111/cpr.13583

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Zhang X, Hou Z, Huang D, et al. Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene. Exp Hematol Oncol. 2023;12(1):19.

[2]	Shah BD, Ghobadi A, Oluwole OO, et al. Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study. J Hematol Oncol. 2022;15(1):170.

[3]	Zhou S, Liu M, Ren F, Meng X, Yu J. The landscape of bispecific T cell engager in cancer treatment. Biomark Res. 2021;9(1):38.

[4]	Cheng YQ, Wang SB, Liu JH, et al. Modifying the tumour microenvironment and reverting tumour cells: new strategies for treating malignant tumours. Cell Prolif. 2020;53(8):e12865.

[5]	Wang C, Liu J, Li W. ‘Off the shelf’ immunotherapies: generation and application of pluripotent stem cell-derived immune cells. Cell Prolif. 2023;56(4):e13425.

[6]	Wang Q, Qin Y, Li B. CD8+ T cell exhaustion and cancer immunotherapy. Cancer Lett. 2023;559:216043.

[7]	Chen C, Li Y. Predictive value of co-expression patterns of immune checkpoint molecules for clinical outcomes of hematological malignancies. Chin J Cancer Res. 2023;35(3):245-251.

[8]	Wu C, Duan L, Li H, et al. PD1hi CD200hi CD4+ exhausted T cell increase immunotherapy resistance and tumour progression by promoting epithelial–mesenchymal transition in bladder cancer. Clin Transl Med. 2023;13(6):e1303.

[9]	Li X, Li Y, Dong L, et al. Decitabine priming increases anti-PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models. J Clin Invest. 2023;133(7):e165673.

[10]	Siddiqui I, Schaeuble K, Chennupati V, et al. Intratumoral Tcf1(+)PD-1(+)CD8(+) T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy. Immunity. 2019;50(1):195-211.e110.

[11]	Im SJ, Hashimoto M, Gerner MY, et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016;537(7620):417-421.

[12]	Zhao Y, Liao P, Huang S, et al. Increased TOX expression associates with exhausted T cells in patients with multiple myeloma. Exp Hematol Oncol. 2022;11(1):12.

[13]	Tan J, Yu Z, Huang J, et al. Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML. Biomark Res. 2020;8:6.

[14]	Wang X, Chen Y, Li Z, et al. Single-cell RNA-Seq of T cells in B-ALL patients reveals an exhausted subset with remarkable heterogeneity. Adv Sci (Weinh). 2021;8(19):e2101447.