MKK4 inhibitor: the hope for liver failure prevention and potential small liver graft transplantation

Yanqiu ZHANG , Hao ZHANG

Chinese Journal of Natural Medicines ›› 2024, Vol. 22 ›› Issue (6) : 483 -485.

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Chinese Journal of Natural Medicines ›› 2024, Vol. 22 ›› Issue (6) :483 -485. DOI: 10.1016/S1875-5364(24)60617-5
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MKK4 inhibitor: the hope for liver failure prevention and potential small liver graft transplantation
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Keywords

Liver regeneration / Partial hepatectomy / MKK4 / Drug discovery and development / First-in-human phase I trial

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Yanqiu ZHANG, Hao ZHANG. MKK4 inhibitor: the hope for liver failure prevention and potential small liver graft transplantation. Chinese Journal of Natural Medicines, 2024, 22(6): 483-485 DOI:10.1016/S1875-5364(24)60617-5

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References

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Zwirner S, Abu Rmilah AA, Klotz S, et al. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure[J]. Cell, 2024, 187(7): 1666-1684.

Funding

National Natural Science Foundation of China(82074068)

National Natural Science Foundation of China(82373912)

National Natural Science Foundation of China(82300685)

National Key R&D Program of China(2023YFD1601400)

Fundamental Research Funds for the Central Universities(2632022YC04)

Jiangsu Outstanding Youth Fund Project(BK20231535)

Natural Science Foundation of Jiangsu Province(BK20221052)

Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB286)

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