The mechanism analysis of KangBingDuKouFuYe in treating throat infection based on network pharmacology and molecular docking

Abstract

KangBingDuKouFuYe (KBDKFY) is widely used to treat inffuenza, upper respiratory tract infections, mumps and other diseases. Due to their diverse active ingredients, it is believed that they may have excellent anti-inflammatory, antibacterial and antiviral effects. Therefore, we believe they may have multiple therapeutic targets for throat inflammation caused by bacterial or viral infections. This study utilizes network pharmacology methods to analyze the therapeutic effects of KBDKFY on Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis, aiming to identify its active ingredients, action targets and related pathways through molecular docking. Additionally, it determines the afffnity between the main active ingredient and the core target before conducting in vitro bacteriostatic tests. The analysis results show that KBDKFY contains multiple active ingredients and potential targets for treating Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis. KEGG enrichment analysis indicates that KBDKFY may have therapeutic effects on these conditions through pathways such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, and others. This provides a theoretical basis for further exploring pharmacological effects and clinical applications of KBDKFY.

Keywords

KangBingDuKouFuYe (KBDKFY) / network pharmacology / molecular docking / Bacterial Pharyngeal Tonsillitis / Viral Pharyngitis