Chemical composition and pharmacological activities of the Phellodendron chinense Schneid

Abstract

Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides reference for its further research and development.

Keywords

Phellodendron chinense Schneid / chemical composition / pharmacological activity

Acknowledgments

This work was financially supported by National Nature Science Foundation of China (81973284) and Scientific Research Foundation of the Education Department of Liaoning province (LJKZ0944).

References

[1] Cui WS, Tian J, Ma ZJ, et al. A new isocoumarin from bark of Pellodendoron chinense. Nat Prod Res, 2003, 17: 427-429.

[2] Lin PC, Hsu KT, Shiu MH, et al. Phellodendron chinense Schneid: A novel yellow-emitting luminescent material for white light-emitting diodes. Sci Rep, 2017, 7: 9009-9015.

[3] Liu RJ. A brief discussion on the chemical constituents and pharmacological effects of Phellodendron chinense. Chin J Mod Dist Educ Chin Med, 2011, 9: 83-84.

[4] Hou XT, Dai H, Zhou JY. Progress in pharmacological research of Phellodendron chinense. J Tradit Chin Med Pharm, 2007, 18: 498-500.

[5] Dong YQ, Hong HX, Zhong GY. Research status and problems of phellodendron quality. Res Pract Chin Med, 2007, 3: 1-4.

[6] Zheng Y, Hui RH, Hou DY. Studies on flavones and anti-oxidation effect of phellodendron. J Anshan Norm Univ, 2010, 32: 35-38.

[7] Xian YF, Mao QQ, Ip SP, et al. Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J Ethnopharmacol, 2011, 137: 1425-1430.

[8] Li X, Zhang W, Qi H, et al. Phenolic constituents of Phellodendron chinense bark. Can J Chem, 2009, 87: 1218-1221.

[9] Ryuk JA, Zheng MS, Lee MY, et al. Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids. Arch Pharmacal Res, 2012, 35: 1045-1054.

[10] Jiang QJ, Chen W, Dan H, et al. Cortex phellodendri extract relaxes airway smooth muscle. Evid Based Complement Alternat Med, 2016: 8703239-8703247.

[11] Cao X, Sun L, Li D, et al. Quality evaluation of phellodendri chinensis cortex by fingerprint chemical pattern recognition. Molecules, 2018, 23: 2307-2317.

[12] Wang H, Yan G, Zhang A, et al. Rapid discovery and global characterization of chemical constituents and rats metabolites of Phellodendri amurensis cortex by ultra-performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry coupled with pattern recognition approach. Analyst, 2013, 138: 3303-3311.

[13] Hu YM, Su GH, Sze SC, et al. Quality assessment of Cortex phellodendri by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry. Biomed Chromatogr, 2010, 24: 438-453.

[14] Sun H, Wang H, Zhang A, et al. Chemical discrimination of cortex Phellodendri amurensis and cortex Phellodendri chinensis by multivariate analysis approach. Pharmacogn Mag, 2016, 12: 41-49.

[15] Fujii A, Okuyama T, Wakame K, et al. Identification of anti-inflammatory constituents in Phellodendri Cortex and Coptidis Rhizoma by monitoring the suppression of nitric oxide production. J Nat Med, 2017, 71: 745-756.

[16] Zhang Z, Liu H, Zhang B, et al. Quantitative and chemical fingerprint analysis for quality evaluation of the dried bark of wild Phellodendron amurense Rupr. based on HPLC-DAD-MS combined with chemometrics methods. Anal Methods, 2015, 7: 2041-2049.

[17] Dangi S, Gupta A, Gupta DK, et al. Green synthesis of silver nanoparticles using aqueous root extract of Berberis asiatica and evaluation of their antibacterial activity. Chem Data Collect, 2020, 28: 100411-100419.

[18] Forouzanfar F, Read MI, Barreto GE, et al. Neuroprotective effects of curcumin through autophagy modulation. IUBMB life, 2019, 71: 1711-1720.

[19] Sadeghnia HR, Kolangikhah M, Asadpour E, et al. Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells. Iran J Basic Med Sci, 2017, 20: 594-601.

[20] Sadeghnia HR, Shaterzadeh H, Forouzanfar F, et al. Neuroprotective effect of safranal, an active ingredient of Crocus sativus, in a rat model of transient cerebral ischemia. Folia Neuropathol, 2017, 55: 206-213.

[21] Forouzanfar F, Hosseinzadeh H, Ebrahimzadeh Bideskan A, et al. Aqueous and ethanolic extracts of Boswellia serrata protect against focal cerebral ischemia and reperfusion injury in rats. Phytother Res, 2016, 30: 1954-1967.

[22] Si Y, Li X, Guo T, et al. Isolation and characterization of phellodendronoside A, a new isoquinoline alkaloid glycoside with anti-inflammatory activity from Phellodendron chinense Schneid. Nat Prod Res, 2021, 154: 105021-105028.

[23] Fan S, Zhang C, Luo T, et al. Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics. Nat Prod Res, 2019, 24: 3679-3692.

[24] Qin S, Lv CH, Wang QS, et al. Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds. Anim Nutr, 2018, 4: 45-51.

[25] Erhan SE, Pârvu AE, Ciorîță A, et al. Chemical composition and anti- inflammatory effect of Phellodendron amurense Rupr. stem bark extract. Not Bot Horti Agrobo, 2023, 51: 13306-13314.

[26] Wang W, Zu Y, Fu Y, et al. In vitro antioxidant, antimicrobial and anti-herpes simplex virus type 1 activity of Phellodendron amurense Rupr. Am J Chin Med, 2009, 37: 195-203.

[27] Li L, Huang T, Tian C, et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Life Sci, 2016, 157: 97-106.

[28] Liu L, Hu C, Zou M, et al. A comparative study of the total phenol and flavonoid contents and biological activities of different medicinal parts of Penthorum chinense Pursh. J Food Meas Charact, 2021, 15: 3274-3283.

[29] Tao W, Li Z, Nabi F, et al. Penthorum chinense Pursh Compound Ameliorates AFB1-Induced Oxidative Stress and Apoptosis via Modulation of Mitochondrial Pathways in Broiler Chicken Kidneys. Front Vet Sci, 2021, 8: 750937-750946.

[30] Lee SH, Kim JH, Kim JS, et al. Discrimination of Phellodendron amurense and P. chinense based on DNA barcode and chemical analysis. Arch Pharm Res, 2012, 35: 1979-1986.

[31] Wang Y, Zhang P, Wang X, et al. Phellodendron chinense Schneid extract ameliorates diabetic nephropathy by regulating the AMPK/SIRT1/PGC-1α signaling pathway. J Cell Mol Med, 2019, 23: 1451-1461.

[32] Li Y, Wang Y, Zhang P, et al. Palmatine ameliorates diabetic nephropathy by suppressing glomerular endothelial cell pyroptosis. J Cell Mol Med, 2019, 23: 2141-2151.