Chemical composition and pharmacological activities of Atractylodes lancea: A review

Abstract

Atractylodes lancea (called Cangzhu in China) is a medicinal plant that has long been used as tonic agent in various ethno-medical systems in East Asia, especially in China, for the treatment of gastrointestinal dysfunction, cancer, osteoporosis, obesity and fetal irritability. We used the TCMSP database to search for the main active ingredients and traditional Chinese medicine targets of Atractylodes macrocephala. There are a total of 38 related articles, of which 27 are closely related to chemical composition and activity. This study reviews the chemical components and pharmacological effects of A. lancea, aiming to provide reference for its further research and development.

Keywords

Atractylodes lancea / chemical composition / pharmacological activities

Acknowledgments

This work was financially supported by National Nature Science Foundation of China (81973284) and Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).

References

[1] Yang B. The Study on Extraction and the Mechanism of Inhibiting AChE of Biatractylolide. Master Thesis of Hunan Normal University, Changsha, 2015.

[2] Yang E, Zhong YM, Feng YF. Advance on the chemical constituents and pharmacological effects of Atractylodes macrocephala Koidz. J Guangdong Pharm Univ, 2012, 28: 218-221.

[3] Yang GW, Zhu XQ, Wang X, et al. The long-term toxicity of volatile oil emulsion from Atractylodes macrocephala. Chin Rem Clin, 2003, 3: 411-412.

[4] Yao CM, Yang XW. Bioactivity-guided isolation of polyacetylenes with inhibitory activity against NO production in LPS-activated RAW264.7 macrophages from the rhizomes of Atractylodes macrocephala. J Ethnopharmacol, 2014, 151: 791-799.

[5] Ye Y, Chou GX, Wang H, et al. Effects of sesquiterpenes isolated from largehead Atractylodes rhizome on growth, migration, and differentiation of B16 melanoma cells. Integr Cancer Ther, 2011, 10: 92-100.

[6] Yosioka I, Nishino T, Tani T, et al. On the constituents of the rhizomes of Atractylodes lancea DC var. chinensis Kitamura (“Jin-changzhu”) and Atractylodes ovata DC (“Chinese baizhu”). The gas chromatographic analysis of the crude drug “zhu”. Yakugaku zasshi, 1976, 96: 1229-1235.

[7] Zhang JD, Cao G, Xia YH, et al. Fast analysis of principal volatile compounds in crude and processed Atractylodes macrocephala by an automated static headspace gas chromatography-mass spectrometry. Pharmacogn Mag, 2014, 10: 249-253.

[8] Zhang JK, Dou DQ, Wang B, et al. Textual research on Atractylodis macrocephalae rhizoma. Lishizhen Med Mater Med Res, 2013, 24: 2222-2224.

[9] Zhang JY, Deng ZH, Jin LY, et al. Spleen-derived anti- inflammatory cytokine IL-10 stimulated by adipose tissue-derived stem cells protects against type 2 diabetes. Stem Cells Dev, 2017, 26: 1749-1758.

[10] Zhang N, Liu C, Sun TM, et al. Two new compounds from Atractylodes macrocephala with neuroprotective activity. J Asian Nat Prod Res, 2017, 19: 35-41.

[11] Zhang XL, Wang L, Xu L, et al. Effects of Atractylodes macrocephala on the cytomembrane Ca2±activated K+ currents in cells of human pregnant myometrial smooth muscles. J Huazhong Univ Sci Technol Med Sci, 2008, 28: 200-203.

[12] Zhang YQ, Xu SB, Lin YC. Gastrointestinal inhibitory effects of sesquiterpene lactones from Atractylodes macrocephala. J Chin Med Mater, 1999, 22: 636-640.

[13] Zhao AS, Sun YL, Zhang LS. Safety assessment of Baizhu. Chin J Public Health, 2006, 22: 43-45.

[14] Zhao YJ, Xu WH, Shen XL, et al. Study on TLC identification and UPLC determination method of atractylenolide in Atractylodes macrocephala. China J Chin Mater Med, 2017, 42: 531-535.

[15] Zheng L. Phylogeny of Atractylodes (Asteraceae) and Studies on Population Genetics and Domestication of Atractylodes macrocephala Koidz. Doctor thesis of Zhejiang University, Hangzhou, 2013.

[16] Zheng L, Shao ZD, Wang ZC, et al. Isolation and characterization of polymorphic microsatellite markers from the Chinese medicinal herb Atractylodes macrocephala (Asteraceae). Int J Mol Sci, 2012, 13: 16046-16052.

[17] Zhou HH, Xu ZL, Yang RQ. Inhibition effect of Atractylodes macrocephala extractive on myometrial smooth muscle cells. J Anhui TCM Coll, 1993, 12: 39- 40.

[18] Zhou J, Qu F, Barry JA, et al. An atractylodes macrocephala koidz extract alleviates hyperandrogenism of polycystic ovarian syndrome. Int J Clin Exp Med, 2016, 9: 2758-2767.

[19] Zhou RB, Wu J, Tong QZ, et al. Studies on volatile oil from Atractylodes macrocephala with different distill methods. J Chin Med Mater, 2008, 31: 229-232.

[20] Brundrett MC. Mycorrhizal associations and other means of nutrition of vascular plants: understanding the global diversity of host plants by resolving conflicting information and developing reliable means of diagnosis. Plant Soil, 2009, 320: 37-77.

[21] Cao G, Cai H, Zhang JD, et al. Rapid determination of the main compounds in crude and processed Atractylodes macrocephala using Fourier transform infrared spectroscopy with attenuated total reflectance. Anal Lett, 2014, 47: 616-626.

[22] Chen HP. Study on the Mechanism of Atractylodes Fried by Soil to Strengthen Spleen and Relieve Diarrhea. Doctor Thesis of Chengdu University of Traditional Chinese Medicine, Chengdu, 2011.

[23] Chen QH, Li P, Yang HD, et al. Sensitive capillary GC-MS-SIM determination of atractylenolide I and atractylenolide III in Atractylodes Macrocephala. Anal Lett, 2009, 42: 2547-2555.

[24] Chen ZL. The acetylenes from Atractylodes macrocephala. Planta Med, 1987, 53: 493-494.

[25] Chen ZL, Cao WY, Zhou GX, et al. A sesquiterpene lactam from Atractylodes macrocephala. Phytochemistry, 1997, 45: 765-767.

[26] Chi YM, Li W, Wen HM, et al. Studies on separation, purification, and chemical structure of polysaccharide from Atractylodes macrocephala. J Chin Med Mater, 2001, 24: 647-648.

[27] Chinese Pharmacopoeia. Editorial Committee of Chinese Pharmacopoeia. China Medical Science and Technology Press, Beijing, 2015.

[28] Dong HY, He LC, Huang M, et al. Anti-inflammatory components isolated from Atractylodes macrocephala Koidz. Nat Prod Res, 2008, 22: 1418-1427.

[29] Feng X, Wang ZL, Lin YC, et al. Effects of biatractylolide on the AD rats induced by Aβ1-40. Chin Pharmacol Bull, 2009, 25: 949-951.

[30] Flora of China 2015. Editorial Committee of Flora of China. Chinese Academy of Sciences, Science Press, Beijing, pp. 40-41.

[31] Gao HY, Zhu XH, Xi Y, et al. Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med, 2018, 15: 1574-1579.

[32] Ha H, An H, Shim KS, et al. Ethanol extract of Atractylodes macrocephala protects bone loss by inhibiting osteoclast differentiation. Molecules, 2013, 18: 7376-7388.

[33] Han JH, Kim JH, Kim SG, et al. Anti-oxidative compounds from the aerial parts of Atractylodes macrocephala Koidzumi. Yakhak Hoeji, 2007, 51: 88-95.

[34] Han KH, Park JM, Jeong M, et al. Heme oxygenase-1 induction and anti-inflammatory actions of Atractylodes macrocephala and Taraxacum herba extracts prevented colitis and was more effective than sulfasalazine in preventing relapse. Gut Liver, 2017, 11: 655-666.

[35] Hoang LS, Tran MH, Lee JS, et al. Inflammatory inhibitory activity of sesquiterpenoids from Atractylodes macrocephala rhizomes. Chem Pharm Bull, 2016, 64: 507-511.

[36] Hong JZ, Yu YX. Effect of ethanol extracts of Atractylodis Macrocephalae on memory impairment in aging mice. J Dalian Univ, 2015, 36: 75-77.

[37] Huang BS, Sun JS, Chen ZL. Isolation and identification of atractylenolide IV from Atractylodes macrocephala Koidz. Acta Bot Sin, 1992, 34: 614-617.

[38] Baldissera MD, Souza CF, Bottari NB, et al. Purinergic signalling displays an anti-inflammatory profile in the spleen of fish experimentally infected with Aeromonas caviae: modulation of the immune response. J Fish Dis, 2018, 41: 683-687.

[39] Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med, 2014, 7: 421-428.

[40] Jun X, Fu P, Lei Y, et al. Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC. Chin Med, 2018, 13: 59-68.

[41] Deng AP, Li Y, Wu ZT, et al. Advances in studies on chemical compositions of Atractylodes lancea and their biological activities. Chin J Chin Mater Med, 2016, 41: 3904-3913.