Chemical constituents and pharmacological effects of Lonicerae japonicae

Abstract

Lonicera japonica, also known as honeysuckle, is an evergreen shrub in the family of Syzygium. By consulting Sciencedirect databases and Web of Science databases, 79 related articles were found, of which 22 were related to chemical composition and pharmacological activity. These articles show that L. japonica has a wide range of pharmacological activities, including antiviral, anti-tumor, and antioxidant effects. These activities have important applications in the pharmaceutical, food, and fragrance industries. This review focuses on the chemical composition and pharmacological effects of L. japonicae, which is of great significance to the development of new drugs and therapeutic methods.

Keywords

Lonicerae japonicae / chemical composition / pharmacological activity

Acknowledgments

This work was financially supported by National Nature Science Foundation of China (81973284), Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944) and Jiangsu Province Capability Improvement Project through Science, Technology and Education (ZDXYS202207).

References

[1] Li M, Wang Y, Jin J, et al. Inhibitory activity of Lonicerae japonicae extracts against /influenza A virus in vitro and in vivo. Virol Sin, 2021, 36: 490-500.

[2] Du XQ, Shi LP, Cao WF, et al. Add-on effect of Lonicerae japonicae in.the treatment of coronavirus disease 2019: a systematic review and meta-analysis. Front Pharm, 2021, 12: 708636.

[3] Ge L, Wan H, Tang S, et al. Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities. RSC adv, 2018, 8: 35374-35385.

[4] Wang F, Li C, Zheng Y, et al. Study on the anaphylactoid of three phenolic acids in Lonicerae japonicae. J Ethnopharm, 2015, 170: 1-7.

[5] Li JX, Kadota S, Li HY, et al. The effect of traditional medicines on bone resorption induced by parathyroid hormone (PTH) in tissue culture: a detailed study on Cimicifugae rhizoma. J Trad Med, 1996, 13: 50-58.

[6] Wang K, Li W, Li ZF, et al. β-sitosterol inhibits the proliferation of hepatocellular carcinoma cells by targeting CDC25B. J Sun Yat-sen Univ, 2012, 43: 675-684

[7] Zhou B, Li J, Liang X, et al. β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling. Acta Pharm Sin, 2020, 41: 1178-1196.

[8] Gupta A, Atanasov AG, Li Y, et al. Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action. Pharmacol Res, 2022: 106505-106516.

[9] Che J, Zhao T, Liu W, et al. Neochlorogenic acid enhances the antitumor effects of pingyangmycin via regulating TOP2A. Mol Med Rep, 2021, 23: 1-8.

[10] Kucharska AZ, Sokół-Łętowska A, Oszmiański J, et al. Iridoids, phenolic compounds and antioxidant activity of edible Lonicerae japonicaeberries (Lonicera caerulea var. kamtschatica Sevast.). Molecules, 2017, 22: 405-411.

[11] Sharma A, Lee HJ. Lonicera caerulea: An updated account of its phytoconstituents and health-promoting activities. Trends Food Sci Technol, 2021, 107: 130-149.

[12] Wu S, He X, Wu X, et al. Inhibitory effects of blue Lonicerae japonicae (Lonicera caerulea L) on adjuvant- induced arthritis in rats: Crosstalk of anti-inflammatory and antioxidant effects. J Funct Foods, 2015, 17: 514-523.

[13] Park J, Kim Y, Lee C, et al. 3, 5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3/JAK2/STAT3 signaling. Biomed Pharm, 2022, 153: 113549-113557.

[14] Wang H, Tian L, Han Y, et al. Mechanism assay of Lonicerae japonicae for heat-clearing based on metabolites and metabolomics. Metabolites, 2022, 12: 121-136.

[15] Wang Y. Research on Chinese medicine Lonicerae japonicae medicinal ingredients and pharmacological effects. Atlant Press, 2017, 3: 42-45.

[16] Piekarska J, Szczypka M, Gorczykowski M, et al. Evaluation of immunotropic activity of iridoid- anthocyanin extract of Lonicerae japonicaeberries (Lonicera caerulea L.) in the course of experimental trichinellosis in mice. Molecules, 2022, 27: 1949-1955.

[17] Gao D, Ma FT, Sun P. Biological function of Lonicerae japonicae extract and its application in breeding industry. Animal Nut, 2019, 31: 2045-2051.

[18] Zhang B, Niu L, Huang X. Lonicera caerulea juice alleviates alcoholic liver disease by regulating intestinal flora and the FXR-FGF15 signaling pathway. Nutrients, 2023, 15: 4025-4031.

[19] Lu Y, Huang WA, He ZB, et al. Network pharmacology- based strategy for exploring the pharmacological mechanism of Lonicerae japonicae (Lonicer japonica Thunb.) against Newcastle Disease. Evid Based Com Alt, 2022, 6: 1934-1946.

[20] Li C, Tang Y, Gu F, et al. Phytochemical analysis reveals an antioxidant defense response in Lonicera japonica to cadmium-induced oxidative stress. Sci Rep, 2022, 12: 6840-6852.

[21] Liu Z, Tian T, Wang B, et al. Reducing acneiform rash induced by EGFR inhibitors with Lonicerae japonicae therapy: A prospective, randomized, controlled study. Front Pharm, 2022, 13: 835166-835170.

[22] Kim K, Bae ON, Lim KM, et al. Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation. J Pharmacol, 2012, 343: 704-711.