Protective effect of BlingLife®-berry extract on blue light- induced eye damage and its mechanism

Abstract

This study aims to investigate the protective effects of BlingLife®-berry extract on the eyes. BlingLife®-berry extract is a mixture of high-quality natural berries, including blackcurrant, aromia, bilberry and maquiberry. The main active ingredient responsible for theeye-protective effects is anthocyanins. Anthocyanins are natural water-soluble pigments belonging to the flavonoid class, and theyhave multiple benefits, including improving vision, anti-inflammatory and antibacterial properties, and antioxidant effects. Dueto the dual benefits of anthocyanins in protecting vision and eliminating free radicals, this study explores the comprehensive eye protective effects of BlingLife®-berry extract in terms of combating blue light-induced eye damage and oxidative stress-inducedvisual fatigue. The results provide robust evidence for the in vivo effects and further technological applications of BlingLife®-berry extract.

Keywords

BlingLife®-berry extract combination / anthocyanins / antioxidant / protecting vision / eliminating radicals

References

[1] Eggersdorfer M, Wyss A. Carotenoids in human nutrition and health. Arch Biochem Biophys, 2018, 652: 18-26.

[2] Zhang AC, MacIsaac RJ, Roberts L, et al. Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review. BMJ Open, 2018, 8: e020804.

[3] Chen Y, Yeung AWK, Pow EHN, et al. Current status and research trends of lithium disilicate in dentistry: A bibliometric analysis. J Prosthet Dent, 2021, 126: 512-522.

[4] Riva A, Togni S, Franceschi F, et al. The effect of a natural, standardized bilberry extract (Mirtoselect®) in dry eye: a randomized, double blinded, placebo- controlled trial. Eur Rev Med Pharmacol Sci, 2017, 21: 2518-2525.

[5] Steigerwalt RD Jr., Belcaro G, Morazzoni P, et al. Mirtogenol potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects. Clin Ophthalmol, 2010, 4: 471-476.

[6] Kan J, Wang M, Liu Y, et al. A novel botanical formula improves eye fatigue and dry eye: a randomized, double- blind, placebo-controlled study. Am J Clin Nutr, 2020, 112: 334-342.

[7] Waite S, Kolla S, Jeudy J, et al. Tired in the Reading Room: The Influence of Fatigue in Radiology. J Am Coll Radiol, 2017, 14: 191-197.

[8] Hsueh YJ, Chen Y N, Tsao YT, et al. The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. Int J Mol Sci, 2022: 23.

[9] Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis, 2016, 22: 61-72.

[10] Casado A, López-de-Eguileta A, Fonseca S, et al. Outer Nuclear Layer Damage for Detection of Early Retinal Toxicity of Hydroxychloroquine. Biomedicines, 2020, 8.

[11] Zhao Y, Zhao J, Gu Y, et al. Outer Retinal Layer Thickness Changes in White Matter Hyperintensity and Parkinson’s Disease. Front Neurosci, 2021, 15: 741651.

[12] Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis, 2005, 15: 316-328.

[13] Valentine JS, Doucette PA, Zittin Potter S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu Rev Biochem, 2005, 74: 563-593.

[14] Handy DE, Loscalzo J. The role of glutathione peroxidase-1 in health and disease. Free Radic Biol Med, 2022, 188: 146-161.

[15] Li R, Yu L, Qin Y, et al. Protective effects of rare earth lanthanum on acute ethanol-induced oxidative stress in mice via Keap 1/Nrf2/p 62 activation. Sci Total Environ, 2021, 758: 143626.

[16] Shi X, Shang F, Zhang Y, et al. Persimmon oligomeric proanthocyanidins alleviate ultraviolet B-induced skin damage by regulating oxidative stress and inflammatory responses. Free Radic Res, 2020, 54: 765-776.

[17] Li H, Li R, Wang L, et al. Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP 3 inflammasome. J Biochem Mol Toxicol, 2021, 35: e22845.

[18] Zhang X, Peng L, Dai Y, et al. Anti-cataract effects of coconut water in vivo and in vitro. Biomed Pharmacother, 2021, 143: 112032.

[19] Sakr S, Hamed A, Atef M. Betanin ameliorates fipronil- induced nephrotoxicity via activation of Nrf2-HO-1/ NQO-1 pathway in albino rat model. Toxicol Res (Camb), 2022, 11: 975-986.

[20] Vaneev AN, Kost OA, Eremeev NL, et al. Superoxide Dismutase1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases. Biomedicines, 2021, 9: 396.