Chronic myeloid leukemia (CML) is a hematopoietic myeloproliferative disorder. The Chinese prescription Danggui Longhui Wan (DGLHW) has been utilized in CML treatment, but its underlying mechanisms remain unclear. In this study, we gathered 794 constituents, 1249 drug targets, 1654 disease genes and 129 intersection genes. GO and KEGG were used to analyze the function of these genes. Compatibility of prescription study showed that monarch drug, minister drug, assistant and guide drug played a synergistic role in the treatment of CML. In addition, we obtained 20 hub genes and 12 key components. Molecular docking indicated that the main compounds and core proteins had good binding ability. The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK, PI3K/AKT, FoxO and p53 signaling pathways.

Dabie Mountains are located at the junction of Anhui, Henan and Hubei provinces in the East of China. With its varied altitude, climate, and soil texture, Dabie Mountains are extremely rich in wild plant resources. The 12th Traditional Chinese Medicine (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University conducted a study on wild vascular plants resources, especially medicinal vascular plants, through field investigation, literature review and specimen identification. There were 472 species of vascular plants belonging to 347 genera and 125 families collected during July 2018 in this area, of which 424 species were medicinal vascular plants, accounting for 89.83% of the total. From the perspective of medicinal parts, most of the medicinal plants there have values in their roots and rhizomes, as well as the whole plants. The efficacy and characteristics of these pharmaceutical dimensions were also summarized and analyzed in detail. Besides, among the wild vascular plants collected, the most dominant families with the biggest numbers of species are Compositae, Lamiaceae, Liliaceae, Rosaceae, Leguminosae, Ranunculaceae, Saxifragaceae and Polygonaceae, and the dominant genus are Viola and Sedum. In terms of life form, perennial herbs are dominant, accounting for 55.72% of the total species, followed by some annual (or biennial) herbs, shrubs and lianas. Finally, recommendations are put forward for strengthening the protection and utilization of wild medicinal plant resources in Dabie Mountains.

Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related disorders. This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts. Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds. The total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and aluminum chloride colorimetric methods, respectively. Antioxidant activities were assessed by DPPH, ABTS scavenging assays and the ferric reducing antioxidant power (FRAP) assay. High-Performance Liquid Chromatography (HPLC) with a C18 column and Thermo TSQ Quantum Access Max (LC-MS) were used to determine the levels of gymnemic acid and identify other potential phenolic compounds. The analysis revealed significant antioxidant activities in the fractions. Fraction A showed the highest DPPH and ABTS scavenging activities, and Fraction C demonstrated the highest ferric reducing power. LC-MS analysis identified several phenolic compounds, indicating that these are major contributors to the antioxidant efficacy of the extract. This study provides a detailed phenolic profile and confirms the strong antioxidant potential of Gymnema sylvestre leaf extract, supporting its therapeutic use and further investigation.

Houttuynia cordata is an important traditional Chinese medicine. It is widely used for clearing heat and detoxification, reducing swelling and treating sores, diuresis and dehumidification. It is also used to treat lung carbuncles, ulcers, hemorrhoids, rectal bleeding, spleen and stomach heat, which are caused by excess heat, heat toxicity, dampness, and disease heat. Modern pharmacological experiments have shown that H. cordata has antibacterial, antiviral, immune enhancing, diuretic and other effects. This article reviews the chemical components and biological activities of H. cordata to provide reference for clinical application.