Chemical composition and biological activities of Angelica sinensis

Abstract

Angelica sinensis (A. sinensis), as a kind of Chinese medicine, has the effects of tonifying blood, promoting blood circulation, regulating menstrual flow, relieving pain, moistening bowel and so on. By consulting Sciencedirect database and Web of Science database, 163 related articles were found, of which 36 were related to chemical composition and pharmacological activities of A. sinensis. In this paper, the chemical structures and different derivatives were systematically summarized by reviewing relevant literatures, and the pharmacological effects were also summarized.

Keywords

Angelica sinensis / chemical composition / biological activity

Acknowledgements

This work was financially supported by National Nature Science Foundation of China (81973284) and Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).

References

[1] Wang CD, Mi CF, Joe BL, et al. Composition analysis of volatile oil in the roots and stems of Parsley. Nw J Phar, 2016, 36: 71-72.

[2] Chen JT, Yang CR. Research progress of homologous plants. Nat Pro Res D, 2004, 4: 95-103.

[3] Mi CF, Wang CD, Qiao BL, et al. Study on chemical constituents of Parsley root. Acta Pharmacol Sin, 1995, 12: 6.

[4] Mi CF, Shi HL, Li FX, et al. Study on Chemical constituents of Parsley root Ⅱ. Nat Pro Res D, 1997, 1: 11.

[5] Wu BH, Sui LJ, Zhong XY, et al. Development and utilization of applicable plant resources. Anhui Agric Sci, 2014, 3: 60.

[6] Sun HG, Zhang M, Ji P, et al. Isolation, purification and monosaccharide composition analysis of Angelica polysaccharide. Nat Pro Res D, 2014, 26: 480-485.

[7] Sun YL, Gu XH, Tang J, et al. Isolation, purification and Structure Analysis of Water-soluble polysaccharide from Angelica Sinensis. Chin J Bio, 2006, 25: 1-4.

[8] Wang SC, Shi SS, Cui J, et al. Isolation, purification and structure identification of a heteropolysaccharide from Danggui. Chin J Phar Sci, 2007, 42: 1255-1258.

[9] Zhou T. Study on isolation, structure identification and biological activity of polysaccharide from Angelica sinensis. Wh Hz Uni Sci Tec, 2018, 1: 3-4.

[10] Yan ZK, Niu ZD, Pan N, et al. Analysis of volatile oil from medicinal plants in northeast China. Chin Trad Chin Med, 1990, 7: 35-37.

[11] Ma RJ, Wang Q, Chen XL, et al. Research progress of Angelica Sinensis. Chin H Med, 2002, 3: 236-237.

[12] Li LL. Study on active components of plants based on chemical classification of plants. Cent Sou Uni, 2010, 3: 1.

[13] Wang YP. Pharmacologic research progress of Angelica sinensis. Chongqing Med, 1989, 2: 35-36.

[14] Lao SC, Li SP, Kan Kelvin KW, et al. Identification and quantification of 13 components in Angelica sinensis(Danggui)by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Anal Chm Acta, 2004, 526: 131.

[15] Lin M, Zhu CD, Sun QM, et al. Study on chemical constituents of Angelica sinensis. Chin J Med, 1979, 14: 529.

[16] Wang HY, Chen RX, Xu HZ. Study on chemical constituents of Angelica sinensis. Chin J Chin Mat Med, 1998, 23: 167.

[17] Lin M, Liu CH, Dong HJ. Study on chemical constituents of Angelica sinensis. Prac Chin Med Misc, 1979, 9: 529-534.

[18] Song QY, Fu YB, Liu J, et al. Study on Chemical constituents of Angelica Sinensis. Chin H Med, 2011, 42: 1900.

[19] Huang WH, Song CQ. Study on chemical constituents of Angelica sinensis. Acta Pharmacol Sin, 2003, 38: 680.

[20] Hu CY, Ding XL. Extraction, separation and Structure identification of lactones from volatile oil of Angelica Sinensis. Chin H Med, 2004, 35: 383.

[21] Chen YY, Li XG, Zhang CP, et al. A new phthalein compound in Angelica. J Zhejiang Uni Tec, 2011, 39: 524.

[22] Niu Y, Wang SF. A new phthalein compound in Angelica sinensis. Chin J Chin Materia Medica, 2014, 39: 80.

[23] Chen YZ, Zhang HD, Chen NY, et al. Analysis of Chemical constituents of Angelica Sinensis- Determination of molecular structure of new Angelica lactone. Chin Sci Bulletin, 1983, 19: 1206.

[24] Chen YZ, Zhang HD. Analysis of Chemical Components of Angelica sinensi-Analysis of non-volatile components in roots. Chem J Chi Uni, 1984, 5: 515.

[25] Su DM, Yu SS, Qin HL. New dipolyphthalein derivatives from Angelica sinensis. Acta Pharmacol Sinica, 2005, 40: 141.

[26] Lu XH, Zhang JJ, Zhang XX, et al. Isolation and structure identification of ligustilide dimer from Angelica sinensis. Chin J CN Med, 2008, 33: 2196.

[27] Ming JN, Ke Z. Isolation, structure and bioactivities of the polysaccharides from Angelica sinensis (Oliv.) Diels: A review. Carbohydr Polym, 2012, 89: 713-722.

[28] Hu J, Feng M, Yang H, et al. Study on the reconstruction of hematopoietic function in mice by transplantation of hemopoietic stem/progenitor cells mobilized by Angelica polysaccharides. J Thd Milit Med Uni, 2007, 29: 2236-2239.

[29] Wang YP wish P. Effect of Angelica polysaccharide on proliferation of hematopoietic progenitor cells. Chin J Med, 1996, 76: 363-366.

[30] Wang BH, Ou JP. Protective effect of Angelica sinensis on ECVs04 cells induced by hyperlipemia. Acta Physiologica Sinica, 2001, 53: 240-243.

[31] Li Q, Ou JP. Effect of Angelica sinensis on atherosclerosis of aorta induced by high fat in rabbits. J Hubei Uni Trad Chin Med, 2003, 5: 29-31.

[32] Liu LN, Mei QB. Effect of Angelica essential oil on contraction of uterine smooth muscle in isolated rats. Chin Patent Med, 2004, 26: 308-311.

[33] Wu GT, Liu FL. Effects of volatile oil of Angelica sinensis on isolated tracheoduodenal and vascular smooth muscle. Chin Med Phar Clinic, 2012, 28: 74-76.

[34] Yang TH, Jia M, Mei QB. Regulation of Angelica polysaccharide on immune function in mice. Chin Patent Med, 2005, 27: 563-565.

[35] Feng JQ, Liu ZX, Zuo ZY, et al. Effects of Angelica polysaccharide and Angelica lactone on cellular immune function in mice. Chin Med Immun, 1998, 14: 279-282.

[36] Han T, Hu PB. Research progress on antitumor effects of Angelica extracts. Clinic Rese Chin Med, 2014, 6: 139-141.

[37] Cao W, Li XQ. Structural analysis and antitumor effect of Angelica polysaccharide APS-2a. Chin H Med, 2008, 31: 261-266.

[38] Cao W, Li XQ. Study on the structural characteristics and antitumor effects of Angelica polysaccharide APS- 3c. Nat Pro Res D, 2008, 20: 217-222.

[39] Hua ZS, Wang JW, Song MD, et al. Effects of Angelica polysaccharide on the expression and activation of JAK2 and STAT3 in K562 leukemia cells. Chin J Anato, 2009, 32: 8-11.

[40] Ga o C Y, Ti a n CR, Z hou M. St udy on fre e radical scavenging activity of Lycium barbarum polysaccharides. J Chin Thr Gorg Uni, 2005, 27: 456-458.

[41] Long R, Du JR, Chen SJ. Study on scavenging free radical and antioxidant activity of angelicolactone. J West Chin Phar, 2010, 25: 420-422.

[42] Yang XB, Zhao Y. Component and Antioxidant Properties of PolysaccharideFractions Isolated from Angelica sinensis (OLIV). Bio Phar Bull, 2007, 30: 1884-1890.