Evaluation Criteria and Rationality Analysis of Drug Utilization of Meropenem in a Tertiary Medical Institution in Beijing

Abstract

Objective To establish a drug use evaluation (DUE) standard for meropenem in a tertiary medical institution in Beijing, and to analyze the use of meropenem for promoting the rational use of antibiotics. Methods A criteria of DUE of meropenem was established based on drug instructions, related guidelines and experts’ opinions. Then, 120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study. Results and Conclusion 120 cases of meropenem use involved 8 clinical departments, including 38 cases in the Department of Respiratory Medicine, 25 cases in the Department of Tuberculosis, and 20 cases in the Department of Gastroenterology. The detection rate of pathogenic microorganisms before first use was 79.17%, and the clinical treatment effectiveness rate was 81.67%. The irrational use of meropenem included poor grasp of usage indications, excessively high starting points, inappropriate usage and dosage, non-standard treatment courses, and excessive combination medication. Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem, provide timely feedback on relevant situations, and promote rational clinical medication.

Keywords

meropenem / antibiotics / rational use / drug use evaluation