Extraocular muscles of mdx-mice as a target for cellular therapy: the histological characteristic with use computer morphometrical analysis

S. E. Avetisov; A. S. Pavliuk; M. A. Stenina; A. A. Fedorov; L. P. Krivov; D. S. Nikolaenko; P. Y. Baranov; A. M. Subbot; A. I. Tuhvatulin

Genes & Cells ›› 2008, Vol. 3 ›› Issue (3) :47 -50.

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Extraocular muscles of mdx-mice as a target for cellular therapy: the histological characteristic with use computer morphometrical analysis

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Abstract

Using computer-assisted morphometrycal analysis we show degeneration and regeneration processes in mdx-mouse extraocular muscles. We¢ve also selected statistical criteria for assessment of degeneration rate. Тhus we suggest to use mdx-mouse extraocular muscles as experimental bioilogical model of myodegenerative processes in human extraocular muscles in search, development and effectiveness assessment of different ways of treatment, among them cell-based and gene therapy.

Keywords

mdх-murines / eхtraocular muscles / bioilogical model / morphometria

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S. E. Avetisov, A. S. Pavliuk, M. A. Stenina, A. A. Fedorov, L. P. Krivov, D. S. Nikolaenko, P. Y. Baranov, A. M. Subbot, A. I. Tuhvatulin. Extraocular muscles of mdx-mice as a target for cellular therapy: the histological characteristic with use computer morphometrical analysis. Genes & Cells, 2008, 3(3): 47-50 DOI:

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