The wide using of spinal anesthesia that is technically uncomplicated and highly effective technique makes strict demands to its safety, minimizing of complications and side effects that it is not devoid of unfortunately. In present review the author summarizes data from special literature dedicated to importance of choosing the needle of this or that type in terms of safety and efficiency of SA as well as safety of diagnostic lumbar puncture.

The incidence of chronic post-thoracotomy pain may achieve up to 80% in patients undergone thoracic surgery. Many pathogenic factors are involved in developing of chronic pain and the main of them is injury of intercostal nerves. The neuropathic component of pain occurs in almost half of such patients worsening their status significantly and disrupting their activity. Valuable prophylaxis of chronic post- thoracotomy pain may be provided by preventive using methods of regional analgesia and epidural anesthesia and paravertebral block are the basic techniques for these purpose.

Does continuous femoral block have any advantages over epidural analgesia using patient controlled analgesia (PCA)? This question is still opened. The authors conducted a randomized placebo-controlled trial in order to compare epidural analgesia and continuous femoral block using method of double parallel patient-controlled analgesia after total knee arthroplasty. The results demonstrated that the using of PCA does not increase the consumption of local anesthetic and the number of adverse effects in comparison with epidural analgesia.

Post-operative pain management is the most important component of complex intensive therapy in surgical patients undergone operations differed by volume and traumatic. The key meaning of post-operative pain management is timely assessment of pain severity that defines prescription of analgesics. The authors present modified visual-analog scale (VAS) that allows evidently monitoring pain dynamics in patients for 24 hours. The study was conducted in oncologic patients undergone major cancer surgery on colon. It shows that severity of pain falls mostly to time interval between 3 p.m. and 11 p.m. at 1-3 days and then shifts to the night period (from 11 p.m. to 5 a.m.) at 5-7 days after the operation while using standard method of post-operative analgesia based on opioids, non-steroidal anti-inflammatory drugs and adjuvant.

The lecture is dedicated to post-puncture headache. It includes comprehensive consideration of clinical physiology as well as factors affecting incidence of this complication in parturients undergone cesarean section under spinal anesthesia. Clinical picture and manifestation of the complication are described in the paper.

Sometimes there appeared situations, escaping from the limits of daily «templates» of the disease. We present to your attention the case report of the uncommon severe pain, likely due to injury of one of the lumbosacral plexus nerves, in patient after hysterectomy.

The paper presents the project of clinical guidelines on anesthesia and analgesia at fetus hypoxia and asphyxia developed on the base of guidelines and recommendations of leading world organizations such as World Health Organization, American Academy of Family Physicians, Royal College of Obstetricians and Gynaecologists (RCOG), International Federation of Obstetrics and Gynecology (FIGO) and etc.

The article is dedicated to correct choosing of criteria for comparison of two groups in scientific research. Several important terms and notations are comprehensively considered and clarified such as null hypothesis, significance level, type I and type II error and criteria power