Nonna Georgievna was born in the city of Podolsk, Moscow region. She graduated from the 1st Moscow Medical Institute, after graduating from which in 1949 she worked in Karaganda (in the regional hospital, maternity hospital and at the Department of Obstetrics and Gynecology of the Karaganda Medical Institute).

Theclinical-morphological, immunohistochemical examination of the elongation of uterine cervix (EUC) in patients aged of 29-70 years old was conducted. The correlation of the systemic connective tissue dysplasia (SCTD) with the reconstruction of the tissue architectonics of the cervix, disorders of collagen synthesis, redistribution of the I, III and IV types of collagen was established, which testify the role of SCTD in the pathogenesis of the EUC.

53 pregnancy outcomes for fetuses and newborns, immunomorphologic condition of placentae and organs of 29 stillborn fetuses were studied. Antigens of viruses A (H1N1 and H2N2), B, RC, AD were detected in placenta and organs of stillborn fetuses. Fixed immune complex, containing C3 complement and IgM, IgA, IgG, was observed in nearly 100 % in placenta and rather rarely in fetus organs. Virus antigens were the same in placenta and fetus organs.

On the basis of results of complex morphological, experimental, clinical and hysterographics researches there were established, that the lower uterine segment in labor is special morphofunctional part of uterus, and its contractive activity participates in modulation of contractive activity of myometrium and directly participates in process of cervical dilatation when the cervix is comletely mature.

The research of bone exchange in 80 women after bilateral ovariectomy and in 120 patients in natural menopause with duration of estrogen deficiency 4,3±0,6 years and 4,2±0,8 years respectively was performed. There were used the modern techniques of BMD estimation (DEXA) and biochemical markers of bone remodeling - N-MID osteocalcin, Pyrilincs D, Beta-Cross Laps, alkaline phosphatase. The identical orientation of infringements of bone exchange in both groups was revealed. However, at women after ovariectomy the osteoresorption occured more actively, despite on younger age of participants of research that finds reflection in low values of BMD in all parts of skeleton and high occurrence of bone rarefication. The most informative markers of bone exchange, promoting early diagnostics of metabolic osteopathy were revealed.

Summary: In this article the results of the research of diagnostic importance of myoglobin determination in peripheral blood and amniotic fluid, fetal fibronectin examination in cervicovaginal composition contents of a pregnant woman are represented in prediction of premature birth.

The particularities of Prolactin (PRL) level in the blood serum of women with maintaining menstrual cycle are investigated. It has the important signifity for diagnostics and threatment of transient hyperprolactinemia. The results of investigation have shown, that the PRL level in blood serum of women particularly fluctuated during menstrual cycle with growth in the second half of it. The optimal time of the blood sampling for PRL level measuring in the preserving menstrual cycle is the time of its maximal increase in the end of the hormonal cycle. The hormonal and menstrual cycle of women does not always correspond exactly by duration. The registration of rectal temperature may be used as the method of hormonal cycle control.

The experience of constant embolization of uterine arteries (60 patients) has shown that constant intravascular occlusion of uterine arteries in some cases may be considered as rational intervention and an alternative for organ-saved surgery. Temporary embolization of uterine arteries (20 patients) orientated to decreasing of intraoperative bleeding risk allows to perform reconstructive-plastic uterine surgery in optimal condititons.

Diagnostic hysteroscopy and endometrial biopsy were performed on patients with tubal infertility. Intrauterine pathology were found in 73,7 % cases. Both procedures should be complementary to each other for correct diagnostics.

Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uterine leiomyoma, significant associations were revealed between low incidence of MMP-1 1G/1G genotype, high growth rates of leiomyoma, multifocal growth and more common adenomyosis development, thus presuming a protective role of MMP-1/1G homozygosity in the development of symptomatic myoma and adenomyosis and growth-promoting effect of the 2G allele. Hence, the promoter genotype of MMP-1 may be considered as possible genetic marker to predict clinical course of the uterine leiomyoma.

The performed complex analysis of real value of external multichannel hysterography and internal method of intrauterine pressure investigation has shown that information received by means of these methods using for research of uterine contractive activity can not serve an authentic basis for formation of representations about functional heterogeneity of various myometrial regions of human uterus in labor.

The level of vascular-endothelial growth factor (VEGF) were investigated at physiological pregnancy and in dynamics at preeclamptic pregnancy. It was found out that VEGF levels were lower in preeclampsia group beginning 16 weeks of gestation.

The influence of grandaxin, phenazepam, relanium on the uterine contractile activity of pregnant rats was studied. It has shown that these preparations induced suppression of contractive activity of myometrium after injection of oxytocine. Injection of oxytocine after administration of tranquilizers induced contractive activity of the myometrium.

A retrospective review of material deaths from sepsis in Saint-Petersburg was undertaken for the period 1996- 2004. Maternal mortality ratios from sepsis for that period 12.4 per 100000 live birth. Conclude made, that the treatment of patiens with sepsis during pregnancy or puerperium should be much more intensive.

In this article frequency, etiology, classification and clinical appearance of complications following surgical procedures for stress urinary incontinence are reviewed. Their correction and prophylactics are also presented.

Literature review is performed of modern adenomyosis diagnostics methods, morphologic changes of myometrium, producing diagnostic phenomena are described, comparative analysis of diagnostic value is performed.

Methodical aspects of evidence based physiotherapy application in gynecology are considered in the article. Basis of methodology and advantage of evidence based physiotherapy for the proof of medical effects, choice of treatment strategy (or preventive maintanance) in patients with gynecological diseases are presented. The actual base of controlled trials of medical physical methods have been made last years in gynecology, and the basic directions of practical use of principles of evidence based physiotherapy are presented.

The article is dedicated for famous obstetrician - Gubarev Alexander

At a meeting of the Society of Obstetricians and Gynecologists of St. BEFORE. Otta, with a report

Among domestic publications on placentology, the collective monograph "Extraembryonic and amniotic structures in normal and complicated pregnancies" occupies a special place, significantly expanding and supplementing the existing ideas about the development and functioning of the placenta at different stages of pregnancy, both under normal and pathological conditions.