SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS

A A Alferov; E S Gershtein; D S Naberezhnov; I O Goryatcheva; N E Kushlinskii

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) : 8 -9.

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SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS

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Abstract

The levels proteins of control points of immunity sPD-1, sPD-L1 in serum or plasma of 366 patients with malignant tumors of various nosological forms treated at the N.N. Blokhin National Medical Research Center of Oncology. A correlation of sPD-L1 with the prevalence of the process and the degree of tumor malignancy, as well as a positive correlation with some other tumor markers of blood, was found: VEGF, VEGFR1, MMP-7, MMP-8, TIMP-1.

Keywords

sPD-L1 / sPD-1 / VEGF / VEGFR1 / MMP-7 / MMP-8 / TIMP-1 / sPD-1 / sPD-L1 / VEGF / VEGFR1 / MMP-7 / MMP-8 / TIMP-1 / kidney cancer / ovarian cancer / gastric cancer / bone sarcomas / blood serum / blood plasma

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A A Alferov, E S Gershtein, D S Naberezhnov, I O Goryatcheva, N E Kushlinskii. SOLUBLE FORMS OF IMMUNE CHECK-POINT RECEPTOR PD-1 AND ITS LIGAND PD-L1 IN PERIPHERAL BLOOD OF ONCOLOGIC PATIENTS: CLINICAL AND PATHOLOGIC CORRELATIONS. Medical academic journal, 2019, 19(1S): 8-9 DOI: