INFLUENCE OF SEMAX ON THE LEVEL OF INTERLEUKIN-1βIN THE CONDITIONS OF “SOCIAL” STRESS

Abstract

A study on the effect of Semax on the level of interleukin-1β under conditions of “social” stress was performed on non-white white rats-males. The formation of a stress reaction under the conditions of “social” exposure was confirmed by the presence of a “stress triad”, including adrenal hypertrophy, a decrease in the number of eosinophils in the peripheral blood and the presence of erosive and ulcerative lesions of the gastric mucosa. The level of serum IL-1β was determined by the method of enzyme-linked immunosorbent assay (ELISA). “Social” stress, formed as a result of inter-male confrontations, is accompanied by an increase in cytokine production, manifested by an increase in the concentration of interleukin-1β. Against the background of Semax administration to stressed animals, we can speak of this representative from the group of neuropeptides, as a possible means of correction, contributing to a decrease in the level of IL-1β.

Keywords

Semax / “social” stress / immune system / interleukin-1β

References

[1] Абрамов В.В., Абрамова Т.Я. Интерлейкин-1 в цитокиновой сети: фундаментальные и прикладные аспекты // Успехи современной биологии. - 2007. - Т. 127. - № 6. - С. 570-579.

[2] Левицкая Н.Г., Глазова Н.Ю., Себенцова Е.А., и др. Исследование спектра физиологической активности аналога актг 4-10 гептапептида семакс // Нейрохимия. - 2008. - Т. 25. - № 1. - С. 111-118.

[3] Kudryavtseva NN. The sensory contact model for the study of aggressive and submissive behaviors in male mice. Aggress Behav. 1991;17(5):285-291.

RIGHTS & PERMISSIONS

Yasenyavskaya A.L., Samotrueva M.A., Myasoedov N.F., Andreeva L.A.