INFLAMM-AGING: THE HYPOTHESIS OF THE INFLAMMATION ROLE IN ALZHEIMER DISEASE PROGRESS

I M Kventoy; N S Linkova; A S Diatlova; V A Zuev; T V Kventaia

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :88 -91.

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INFLAMM-AGING: THE HYPOTHESIS OF THE INFLAMMATION ROLE IN ALZHEIMER DISEASE PROGRESS

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Abstract

Inflamm-aging - the term, describes the development of chronic inflammation during aging without the infection pathology. It is supposed, that inflamm-aging is one of the reason of age-related pathology, partially, Alzheimer disease (AD). There were done comparative analysis of AD (Аβ42, τ-protein, р16) and inflammation (IL-6, TGFα, NF-kB) markers in hippocamp and blood lymphocytes in elderly and old people. It was shown, that expression of investigated signal molecules in hippocamp and lymphocytes of elderly and old AD people increased in comparison with people of control group (without neurodegenerative pathology). Thus, inflammation mediators play important role in AD pathogenesis and can be the potential target for neuropathology therapy.

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inflamm-aging / Alzheimer disease / blood lymphocytes / cytokines

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I M Kventoy, N S Linkova, A S Diatlova, V A Zuev, T V Kventaia. INFLAMM-AGING: THE HYPOTHESIS OF THE INFLAMMATION ROLE IN ALZHEIMER DISEASE PROGRESS. Medical academic journal, 2019, 19(1S): 88-91 DOI:

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