THE EFFECT OF VITAMIN D ON THE SEVERITY OF DEPRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS

V A Aleksandrov; N V Nikitina; L N Shilova; N I Aleksandrov; N V Emelianov; E E Aleksandrova; E E Mozgovaya; I A Zborovskaya

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :197 -199.

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THE EFFECT OF VITAMIN D ON THE SEVERITY OF DEPRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS

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Abstract

Objective: to study the dependence of depressive disorders in patients with rheumatoid arthritis (RA) on vitamin D deficiency in blood serum. Material and methods. 88 women were examined (mean age - 54.2 ± 12.0 years, disease duration - 9.0 [3.5; 16.0] years) with a reliable diagnosis of RA. An enzyme immunoassay was used to determine the 25(OH)D in the serum of patients with RA. Depression was assessed using the Beck scale. Results. In 89.8% of patients, an insufficient level of 25(OH)D was detected in the serum. The presence of depression was observed in 66% of patients with RA. A negative correlation of average power (r = -0.38) was found between the the level of 25(OH)D and the severity of depression. A negative correlation of average power (r = -0.38) was found between the the level of 25(OH)D and the severity of depression. The relationship between 25(OH)D and ESR (r = 0.29), depression and intake (r = 0.22) and dose (r = 0.26) of corticosteroid hormones, the number of painful joints (r = 0.25) indicates on the involvement of these predictors and their mutual influence in metabolic and psychological processes in RA. Vitamin D is indirectly involved in inflammatory changes and central sensitization, which provokes psychological disorders in patients with RA. Conclusion. Correction of the deficiency of 25(OH)D can positively affect the reduction of the severity of depression and pain in RA.

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rheumatoid arthritis / vitamin D / depression

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V A Aleksandrov, N V Nikitina, L N Shilova, N I Aleksandrov, N V Emelianov, E E Aleksandrova, E E Mozgovaya, I A Zborovskaya. THE EFFECT OF VITAMIN D ON THE SEVERITY OF DEPRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS. Medical academic journal, 2019, 19(1S): 197-199 DOI:

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References

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[1]	Santos EF, Duarte CM, Ferreira RO. Multifactorial explanatory model of depression in patients with rheumatoid arthritis: a structural equation approach. Clin. Exp. Rheumatol. 2018;(12).

[2]

Aleksandrov AV, Nenasheva NV, Degtjarev VK, et al. Dinamika otdel’nyh parametrov psihologicheskogo statusa bol’nyh revmatoidnym artritom i osteoartrozom pod vlijaniem obshhej magnitoterapii. Sovremennye problemy nauki i obrazovanija. 2016;6. URL: http://www.science-education.ru/article/view?id=25595

[3]	Pu D, Luo J, Wang Y. Prevalence of depression and anxiety in rheumatoid arthritis patients and their associations with serum vitamin D level. Clin. Rheumatol. 2018;37(1):179-184.

[4]	Srivastava S, Bhatia MS, Gautam P. Hydroxyvitamin D levels, quality of life, and disability in long-standing patients of somatization. Ind. Psychiatry J. 2018;27(1): 87-91.

[5]	Abdul-Razzak KK, Almanasrah SO, Obeidat BA. Vitamin D is a potential antidepressant in psychiatric outpatients. Int. J. Clin. Pharmacol. Ther. 2018;56(12):585-596.

[6]	Marsh WK, Penny JL, Rothschild AJ. Vitamin D supplementation in bipolar depression: A double blind placebo-controlled trial. J. Psychiatr. Res. 2017;95:48-53.