PROTEASOME MECHANISMS OF THE DEVELOPMENT OF TOLERANCE TO ALLOGRAFT IN WISTAR AND AUGUST RATS WITH DIFFERENT CONTENT OF MONOAMINES IN THE BRAIN

T M Astakhova; Ya D Karpova; G A Bozhok; N M Alabedal’karim; Yu V Lyupina; E I Legach; N P Sharova

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :39 -41.

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PROTEASOME MECHANISMS OF THE DEVELOPMENT OF TOLERANCE TO ALLOGRAFT IN WISTAR AND AUGUST RATS WITH DIFFERENT CONTENT OF MONOAMINES IN THE BRAIN

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Abstract

The aim of the work was to compare proteasome mechanisms of the development of donor-specific tolerance (DST) to ovarian allograft in outbred Wistar rats and inbred August rats with the increased level of monoamines and stress limiting systems in the brain. In spite of DST induction in all animals, engraftment was more effective in Wistar rats. In the liver of all rats with survived allograft, the level of proteasome immune subunt LMP2, evaluated by Western blotting, was significantly higher than in control false-operated rats. This difference was more pronounced in Wistar rats. Besides, in the liver of all rats with survived allografts, the level of proteasome PA28αβ activator was higher than in control. In conclusion, the development of DST is connected with the enrichment of liver proteasome pool by immune forms containing LMP2 subunit and PA28αβ activator. This process is partially suppressed in August rats under stress conditions of the central nervous system.

Keywords

proteasomes / donor-specific tolerance / ovarian allograft / stress of central nervous system

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T M Astakhova, Ya D Karpova, G A Bozhok, N M Alabedal’karim, Yu V Lyupina, E I Legach, N P Sharova. PROTEASOME MECHANISMS OF THE DEVELOPMENT OF TOLERANCE TO ALLOGRAFT IN WISTAR AND AUGUST RATS WITH DIFFERENT CONTENT OF MONOAMINES IN THE BRAIN. Medical academic journal, 2019, 19(1S): 39-41 DOI:

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References

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[1]	Karpova YaD, Bozhok GA, Alabedal’karim NM, et al. Proteasomes and transplantology: Current state of the problem and the search for promising trends. Biology Bulletin. 2017;44(3):237-244.

[2]	Karpova YaD, Bozhok GA, Lyupina YuV, et al. Changes in the proteasome function after Induction of donor-specific tolerance in rats with ovarian allograft. Biology Bulletin. 2012;39(3):244-249.

[3]	Erokhov PA, Lyupina YuV, Radchenko AS, et al. Detection of active proteasome structures in brain extracts: Proteasome features of August rat brain with violations in monoamine metabolism. Oncotarget. 2017;8:70941-70957.