COMBINED ACTION OF ANTIMICROBIAL PEPTIDES AND NONIONIC SURFACTANTS TOWARDS BACTERIA

M S Zharkova; D S Orlov; A A Kolobov; O V Shamova

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :194 -196.

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COMBINED ACTION OF ANTIMICROBIAL PEPTIDES AND NONIONIC SURFACTANTS TOWARDS BACTERIA

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Abstract

Antimicrobial peptides (AMPs) have certain resemblance with surfactants. Using checkerboard titrations and spectrophotometrical analysis of the membrane permeability for chromogenic markers, we found that nonionic surfactants “Tritons” significantly increase the speed of membranolytic action of AMPs, and enhance their antibacterial activity.

Keywords

antimicrobial peptides / Triton X / synergy / antibacterial action / membrane permeabilization

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M S Zharkova, D S Orlov, A A Kolobov, O V Shamova. COMBINED ACTION OF ANTIMICROBIAL PEPTIDES AND NONIONIC SURFACTANTS TOWARDS BACTERIA. Medical academic journal, 2019, 19(1S): 194-196 DOI:

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References

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