PHARMACOLOGICAL CORRECTION BY PHENAZEPAM OF DISORDERS IN INTERACTION OF NERVOUS AND IMMUNE SYSTEMS DURING PREDATOR STRESS IN DANIO RERIO

Abstract

The behavior of Dario rerio fish under stress control (mental trauma modeling) and with the axiolytic drug phenazepam was studied. With the drug phenazepam - tranquilizer fish calm down and float to the top of the aquarium. Typically, this fish was used in research in the field of molecular genetics and developmental biology, but recently it has become attractive in the work on the creation of new drugs and the modeling of various physiological and pathological processes. Danio rerio is a model organism in developmental biology. Most human genes have homologs in zebra fish (70%-80%), and functional kinase domains have 100% identity. The hypothalamic-pituitary-adrenal axis corresponds to that in humans. The aim of our work is to determine the neuropeptides in the brain of Danio rerio after stress effects and the use of phenazepam.

Keywords

behavior / Danio rerio fish / predator / stress / drug phenazepam / tranquilizer / axiolytic / trauma modeling / vital stress

References

[1] Есауленко А.Н., Курапов А.А., Гаврилов Б.А, Косякова Г.П. Цитогенетический мониторинг рыб Каспийского бассейна // «Проблемы морфологии»: материалы Всероссийской конференции. - Сочи, 14-16 мая 2002. - С. 23.

[2] Есауленко А.В., Косякова Г.П. Цитогенетическое изучение кроветворных клеток рыб каспийского бассейна // «Актуальные проблемы генетики»: материалы 2-й конференции московского общества генетиков и селекционеров им. Н.И. Вавилова, посвященной 115-летию со дня рождения академика Н.И. Вавилова. - Москва, 20-21 февраля 2003. - Т. 1. - С. 342-343.

RIGHTS & PERMISSIONS

Kosyakova G.P., Blazhenko A.A., Lebedev A.A.