The effect of orexin A application on the reaction of microglia cells body size stimulated by LPS injection

A P Synchikova; H Horiuchi; J Nabekura

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :232 -233.

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The effect of orexin A application on the reaction of microglia cells body size stimulated by LPS injection

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Abstract

The purpose of this study is to determine the effect of orexin A to LPS-activated microglia by investigating the morphological change. The effect of orexin on the level of LPS-activated microglia activation during the transition to the M1 phenotype was determined, which can be studied by measuring the cell area of the body.

Keywords

microglia / orexin A / cell body of microglia

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A P Synchikova, H Horiuchi, J Nabekura. The effect of orexin A application on the reaction of microglia cells body size stimulated by LPS injection. Medical academic journal, 2019, 19(1S): 232-233 DOI:

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References

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[1]	Hu X, Li P., Guo Y, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43(11):3063-70.

[2]	Willie JT, Chemelli RM, Sinton CM, Yanagisawa M. To eat or to sleep? Orexin in the regulation on feeding and wakefulness. Annu Rev Neurosci. 2001;24:429-458.

[3]	Xiong X, White RE, Xu L, et al. Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Stroke. 2013;44(3):764-70.

[4]	Duffy CM, Yuan C, Wisdorf LE, et al. Role of orexin A signaling in dietary palmitic acid-activated microglial cells. Neurosci Lett. 2015;606:140-4.

[5]	Shu Q, Hu Z-L, Huang C, et al. Orexin-A Promotes Cell Migration in Cultured Rat Astrocytes via Ca2+-Dependent PKCα and ERK1/2 Signals. PLoS One. 2014 Apr 18;9(4). https://doi.org/10.1371/journal.pone.0095259.