CORRECTION OF STRESS-INDUCED HORMONAL CHANGES BY THE RIL-2 MEDICATION IN EXPERIMENTAL TRAUMATIC BRAIN INJURY

E E Fomicheva; S N Shanin; T A Filatenkova; N B Serebryanaya

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :199 -200.

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CORRECTION OF STRESS-INDUCED HORMONAL CHANGES BY THE RIL-2 MEDICATION IN EXPERIMENTAL TRAUMATIC BRAIN INJURY

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Abstract

Traumatic brain injury (TBI) leads to steady stress reaction that may substantially influence on posttraumatic period. Stress changes concentration of sex hormones too, that play role of neurosteroids in CNS. The aim of the study was to detect changes in corticosterone and testosterone concentration in serum of experimental animals during recovery period after TBI. And also to find possibility of disturbance correction by cytokine preparation rIL-2 (ronkoleukin). After TBI both experimental and control group of animals get daily injections of recombinant human interleukin-2. TBI decreased the level of corticosterone on 30%, the injection of rIL-2 increased it. Testosterone slightly changed after TBI. But it’s level increased when after TBI the injections of rIL-2 were done. The obtained results can be considered as evidence of the stress reaction normalization in animals after TBI and under the conditions of their treatment with rIL-2.

Keywords

stress-hormones / TBI / rIL-2

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E E Fomicheva, S N Shanin, T A Filatenkova, N B Serebryanaya. CORRECTION OF STRESS-INDUCED HORMONAL CHANGES BY THE RIL-2 MEDICATION IN EXPERIMENTAL TRAUMATIC BRAIN INJURY. Medical academic journal, 2019, 19(1S): 199-200 DOI:

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[1]	Rybakina EG, Shanin SN, Fomicheva EE, et al. Cellular molecular mechanisms of changes in the protective functions of the body in traumatic brain injury and an attempt at treatment. Medical Academic Journal. 2014;14(4):55-62.