The Impact and the Prevention of Burnout on Psychic activity and Nervous and Immune Systems

Abstract

The study of the mechanisms of functioning of the immune system under stress does not lose its relevance for decades. An important factor in the neuroendocrine regulation of immunity during stress is the endogenous opioid system. In the present work, we evaluated the effect of various cold stress variants on the production of cytokines IL-1β and IL-10 by the cells of the mouse peritoneal cavity under conditions of blockade of opiate receptors. It was established that acute and chronic cold stress, regardless of duration, did not affect the production of IL-1β and increased the production of IL-10 by peritoneal macrophages, this effect was canceled by the introduction of naloxone. The effect of chronic cold stress on IL-10 production depended on cell activation. In all variants of stress, an increase in plasma corticosterone concentration was observed, which did not depend on the blockade of opiate receptors. The work was performed in the framework of the state task, the number of the state registration of the topic No. 01201353248.

Keywords

burnout / conflict / psychic activity / nervous and immune systems / prevention

References

[1] Freudenberger HJ. Staff burn-out. Journal of Social Issues. 1974;(30):159-165.

[2] Maslach C. Burned-out. Human Behavior. 1976;(5):16-22.

[3] Maslach C, Jackson SE. The measurement of experienced burnout. Journal of Organizational Behavior. 1981;(2):99-113.

[4] Freud S. Analysis Terminable and Interminable. In: J Strachey. The Standard Edition of the Complete Psychological Works of Sigmund Freud. Vol. XXIII. Hogarth Press: London; 1964. P. 232.

[5] Radtchenko-Draillard SV. L’étude psychanalytique de la résolution des conflits dans les interactions internationales et la négociation. Thèse de doctorat en psychologie. Université Sorbonne Paris Cité- Paris Diderot; 2016. P. 15-24.

[6] American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: VA; 2013.

RIGHTS & PERMISSIONS

Radtchenko-Draillard S.