DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION

A N Trofimov; O E Zubareva; A P Schwarz; E A Veniaminova; K Fomalont; V M Klimenko

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :119 -120.

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DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION

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Abstract

Disorders of the CNS development at an early age caused by various types of perinatal pathology, such as infectious diseases, trauma, hypoxia and ischemia, often lead to the development of cognitive brain dysfunctions in adulthood. Proinflammatory cytokines play key role in these pathological processes and can affect the expression of genes involved in the regulation of neuroplasticity. This article describes the changes in the expression of fibroblast growth factor-2 (Fgf2), as well as genes encoding matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), proteins that by intercellular matrix re-modeling are involved in the regulation of neuroplasticity.

Keywords

neonatal pathology / brain development / cognitive deficit / lipopolysaccharide / neuroplasticity

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A N Trofimov, O E Zubareva, A P Schwarz, E A Veniaminova, K Fomalont, V M Klimenko. DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION. Medical academic journal, 2019, 19(1S): 119-120 DOI:

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References

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[1]	Zubareva OE, Klimenko VM. Increases in Proinflammatory Cytokine Levels at Early Ages as a Risk Factor for the Development of Nervous and Mental Pathology. Neuroscience and Behavioral Physiology. 2013;43(4):535-541.

[2]	Williamson LL, Sholar PW, Mistry RS, et al. Microglia and memory: modulation by early-life infection. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2011;31(43):15511-21.

[3]	Zavitsanou K, Dalton VS, Walker AK, et al. Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse. 2013;67(6):290-299.

[4]	Vereker E, Campbell V, Roche E, et al. Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1. The Journal of biological chemistry. 2000;275(34):26252-8.

[5]	Tishkina A, Stepanichev M, Kudryashova I, et al. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behavioural brain research. 2016;304:1-10.

[6]	Trofimov A, Strekalova T, Mortimer N, et al. Postnatal LPS Challenge Impacts Escape Learning and Expression¬ of Plasticity Factors Mmp9 and Timp1 in Rats: Effects of Repeated Training. Neurotoxicity research. 2017;32(2):175-186.

[7]	Veniaminova EA, Zubareva OE. The changes in exploratory behavior and Fgf2 gene expression in cells of the rat brain after the early postnatal administration of bacterial lipopolysaccharide. Neurochemical Journal. 2015;9(2):127-132.