ESPECIALLY CELLULAR IMMUNITY IN PATIENTS WITH TRAUMATIC BRAIN INJURY OF DIFFERENT SEVERITY IN ACUTE PERIOD

A O Norka; R N Kuznetsova; S V Kudryavtsev; S N Kovalenko; M K Serebriakova; S V Vorobyev

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :96 -98.

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ESPECIALLY CELLULAR IMMUNITY IN PATIENTS WITH TRAUMATIC BRAIN INJURY OF DIFFERENT SEVERITY IN ACUTE PERIOD

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Abstract

Currently, it is known that in response to brain damage a reaction from the immune system is triggered, but its role in the formation of clinical manifestations remains a little-studied problem to date. Using multicolor cytometric analysis, a study was conducted to determine the number of Th1-, Th2-, Tfh- and Th17-cells among CD45RA-negative CD3+CD4+ cells in a group of patients with mild TBI (M-TBI, n = 20) and with moderate to severe TBI (MS-TBI, n = 16) and a group of conditionally healthy donors (n = 30). The imbalance between Th2 cells and Th17 cells was found in patients with TBI in the acute period, which probably predetermines the course of the disease and the development of complications.

Keywords

flow cytometry / traumatic brain injury (TBI) / CD45RA-negative (memory) CD3+CD4+ lymphocytes

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A O Norka, R N Kuznetsova, S V Kudryavtsev, S N Kovalenko, M K Serebriakova, S V Vorobyev. ESPECIALLY CELLULAR IMMUNITY IN PATIENTS WITH TRAUMATIC BRAIN INJURY OF DIFFERENT SEVERITY IN ACUTE PERIOD. Medical academic journal, 2019, 19(1S): 96-98 DOI:

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References

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