THE EFFECT OF KE PEPTIDE ON THE TELOMERE LENGTH OF PHA-STIMULATED HUMAN LYMPHOCYTES

V Kh Khavinson; N S Linkova; A A Pendina; O A Efimova; A S Koltsova; M I Krapivin; A V Tikhonov; L I Petrova; A V Petrovskaia-Kaminskaia; V S Baranov

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :166 -168.

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THE EFFECT OF KE PEPTIDE ON THE TELOMERE LENGTH OF PHA-STIMULATED HUMAN LYMPHOCYTES

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Abstract

The goal of the research is to study the effect of KE peptide on telomere length of PHA-stimulated blood lymphocytes of young and middle-aged men. 11 blood lymphocyte samples were enrolled in the analysis. Relative telomere length was measured using fluorescence in situ hybridization with DNA-probes specific to telomere sequences of human chromosomes. 5 cases of significant telomere length alteration were registered. These changes were more frequent registered in middle-aged people: 4 invents cases versus 1. KE peptide increased telomere length in blood lymphocytes of middle-aged people if it was basically low and, vice versa, decreased the basically high telomere length.

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KE peptide / telomeres / lymphocytes / age

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V Kh Khavinson, N S Linkova, A A Pendina, O A Efimova, A S Koltsova, M I Krapivin, A V Tikhonov, L I Petrova, A V Petrovskaia-Kaminskaia, V S Baranov. THE EFFECT OF KE PEPTIDE ON THE TELOMERE LENGTH OF PHA-STIMULATED HUMAN LYMPHOCYTES. Medical academic journal, 2019, 19(1S): 166-168 DOI:

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References

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[1]	Хавинсон В.Х. Пептидная регуляция старения. - СПб.: Наука, 2009. - 50 с.

[2]	Кузнецова Т.В., Логинова Ю.А., Чиряева О.Г., и др. Цитогенетические методы. Медицинские лабораторные технологии. Т. 2. / Ред. А.И. Карпищенко. - М.: ГЭОТАР-Медиа, 2013. - 792 c.

[3]	Севостьянова Н.Н., Линькова Н.С., Полякова В.О., и др. Иммуномодулирующее действие вилона и его аналога в культурах клеток тимуса человека и животных // Клеточные технологии в биологии и медицине. - 2012. - № 4. - С. 220-223.

[4]	Щербак В.А., Патеюк А.В. Влияние вилона на иммунный ответ при остром иммобилизационном стрессе у крыс // Сибирский медицинский журнал. - 2004. - Т. 44. - № 3. - С. 26-29.

[5]	Khavinson VKh, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull. Exp. Biol. Med. 2004;137(1):78-81.

[6]	Yang M, Jiang P, Jin C, Wang J. Longer Telomere Length and its Association with Lower Levels of C-Peptide. Front Endocrinol (Lausanne). 2017;8:244.

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Khavinson V.K., Linkova N.S., Pendina A.A., Efimova O.A., Koltsova A.S., Krapivin M.I., Tikhonov A.V., Petrova L.I., Petrovskaia-Kaminskaia A.V., Baranov V.S.