THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN

E S Umnyakova; I A Krenev; S V Legkovoy; A V Sokolov; O N Rogacheva; T V Ovchinnikova; V N Kokryakov; M N Berlov

Medical academic journal ›› 2019, Vol. 19 ›› Issue (1S) :187 -188.

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THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN

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Abstract

The complement system and antimicrobial peptides (AMPs) are known to be vital humoral factors of innate immunity. Earlier we showed the double-sided influence of arenicin-1 (Ar-1), the AMP from a sea polychaeta Arenicola marina, on the complement activation. In this work we studied the binding of Ar-1 to C3b protein, the fragment of the central complement component C3, using surface plasmon resonance. We also performed molecular docking and molecular dynamics of interaction between C3b fragment - C3c - and Ar-1. All these data showed that the influence of Ar-1 on complement activation might be realized through the interaction with C3b, the most important component for complement activation. Ar-1 may be used for the design of new complement regulators for treating complement-related diseases.

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complement system / antimicrobial peptides / arenicin-1 / C3b protein

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E S Umnyakova, I A Krenev, S V Legkovoy, A V Sokolov, O N Rogacheva, T V Ovchinnikova, V N Kokryakov, M N Berlov. THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN. Medical academic journal, 2019, 19(1S): 187-188 DOI:

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