Sixteen cases of Kaposi's sarcoma treated with photodynamic therapy with intralesional injection of photosensitizer Photoditazine are described. The review of national and foreign literature (22 references) is presented.

The case of association of two skin tumors, i.e. Kaposi's sarcoma and T-cell skin lymphoma (erythrodermic type mycosis fungoides), in a single patient is described. Diagnoses were verified histologically and immunohistochemically.

Matrix metalloproteinase-9 (MMP-9) expression in 102 patients with melanocytic skin neoplasms was analyzed. An amount of MMP-9 in skin melanoma with different localization and Clarks level of invasion and in benign skin neoplasms was assessed.

There is a literature review of national and foreign publications on a problem of different multiple neoplasms development under the chronic exposure of solar radiation. The case of a multiple tumors development in 73 years old patient with dermatoheliosis is discussed.

There is a case report of 86 years old patient with Wegener's granulomatosis. The literature review (18 references) on the rare disease is supplied.

There is a case report of a patient with tuberculosis of skin (TS) in a form of secondary scrofuloderma. According to modern data TS is a respectively rare dermatological condition. The diagnosis of TS is a serious challenge for a physician particularly as a result of low suspicion on the disease. It is suggested that TS is more frequent than it is diagnosed.

There is a review of pediculicidal medications used for pediculosis treatment and data on drug resistance in lice. The authors have closely analyzed a spectrum of active compounds of medications used for pediculosis capitis since 1960s. As a result it is noted that about 80% of modern pediculicidal medications approved in Russia contain pyrethroids. In relation to recent problem of lice resistance to permethrin it is recommended to use alternative pediculicidal medications with other mechanisms of action.

Children living in a board school in the Oryol Region were examined by medical team to reveal prevalence and pattern of distribution of dermatological disorders. Dermatoses were diagnosed with a high prevalence of 95.9%. Two or more skin diseases were found in 51.1% of cases. Infectious and noninfectious dermatological diseases were almost equally prevalent, 48.2% and 51.8% respectively. Among infectious dermatoses mycoses corresponded more than 1/3, viral dermatoses -- about 1/3, pyodermia -- about 1/4. Scabies was diagnosed in 6 (6.7%) of adolescents of 16--18 years old. The epidemiological analysis has revealed primary pseudoirradiate nidus of infestation, i.e. all the patients were infected beyond the foster children group. True irradiation started in the board school, however not due to co-residence in the same living room, but as a result of a close contact during wrestling classes.

The authors have reviewed national and foreign publications (34 references) on a problem of association of circumscribed scleroderma with autoimmune diseases and autoantibodies. The original study was based on examination of 156 patients with different types of circumscribed scleroderma. The last was associated with autoimmune diseases and autoantibodies spectrum in 20 patients. Those patients are proposed to be included in a risk group of disease transformation into systemic scleroderma.

There is a case report of patient with circumscribed type of Levers bullous pemphigoid developed after cordaron intake. Combined therapy with a use of plasmapheresis caused full regress of lesions.

Clinical presentations were retrospectively studied in 160 patients with multibacterial types of leprosy. Among them 60 patients had reaction in a form of erythema nodosum leprosum. Concentrations of serum lactoferrin and antibodies to Њycobacterium leprae were measured.

Authors present the most interesting literature data related to epidemiology, pathogenesis, classification, diagnostics, differential diagnosis and treatment of fungal intertrigo. Results of the study including 40 patients with mycosis of skin folds are also described. A complex clinical and laboratory assessment of effectiveness of Pimafucort créme was conducted in these patients. The results allow to conclude that treatment of different forms of intertriginous mycoses with this medication is moderately effective and highly safe. Pimafucort créme can be recommended for extensive use in in-patient and out-patient departments.

Typical mistakes in prescription and usage of differin are analyzed. Structure and unique kinetics of this preparation are described and results of effectiveness studies of different drug formulations are presented. Authors present facts illustratinf high effectiveness and safety of differin in acne therapy.

Data about etiology, pathogenesis, pathomorphological picture of vulvovaginal and gingival syndrome are presented. Diagnostics and treatment of this disorder are discussed. A case of vulvovaginal and gingival syndrome in a young woman is presented.

Review of literature concerning use of molecular diagnostic methods in studies of syphilis infestion is presented. Leaders in this area of scientific studies are pointed out including polymerase chain reaction (PCR), real time polymerase chain reaction (PCR-RT), nucleic acid sequence-based amplification (NASBA) with real-time detection of the amplification products. Author present the results of own study designed for comparison of direct method NASBA-RT and PCR-RT. As a target a fragment of 16s аRNA gene of Treponema pallidum was used.

Authors present their experience of use of electronic medical cards in dermatologic in-patient department.