The paper presents the comparative results of photodynamic therapy (PDT) in 60 patients with basal-cell carcinoma (BCC) depending on the route of administration with the photosensitizer (PS) Photoditasine. The efficiency of BCC treatment has been found to depend on the route of administration of the PS and to yield the best results when locally used. It is noted that PDT with the intrafocal administration of the PS Photoditasine leads to the recovery of stages T1 and T2 nodular BCC in 100% of cases; moreover, it induces no systemic adverse reactions, requires no light regimen observance, significantly reduces the time of wound healing, and provides excellent and good cosmetic results significantly more frequently.

The epidemiological and clinicomorphological features of basal-cell carcinoma (BCC) of the skin were studied in the town of Perm. BCC constituted 94.5% of the epidermal malignancies. BCC morbidity rates were stably high with an average annual rate of 38.18 ± 0.9 per 100,000 population. There was a significant preponderance of women (66.8%) among the patients with BCC. The clinicomorphological features of BCC were character by a higher proportion of ulcerative varieties of the tumor (50%) of complex histological structure and morphea-like structures (18.4%). An immunohistological study revealed a high proliferative index (Ki-67 more than 30% of the expressing nuclei) of the morphea-like type of BCC.

The expression of StAR and peripheral benzodiazepine receptor (PBR) was studied in the skin of patients with melanoma and in those with benign melanocytic nevi. The presence of StAR was first determined in the skin of patients with this abnormality. There was a reduction in the expression of StAR and PBR as compared with the indices of normal epidermis.

The paper describes a case of multiple foci of recurrent benign lymphoplasia in patients with borreliosis that was provoked by corticosteroids and regressed during specific antibacterial therapy.

The paper provides data on the detection of antibodies to M. leprae during an immunochemical study of acute-phase proteins in patients with lepromatous lepra with the development of lepra reactions.

The visually unchanged skin and psoriatic plaques were ultrasonically studied in 30 patients with psoriasis at its different stages.

The paper presents the results of complex therapy in patients with desquamative lesions of the skin, by using enterosorbents and immunomodulators.

The autonomic and hormonal systems were studied in 72 patients with dermatitis seborrhoica (DS); the detected disorders were corrected by transcranial electrostimulation of the brainstem with a Transair-2 apparatus. The findings suggest that this technique shows a high therapeutic effectiveness and a good tolerability in DS.

The paper considers the etiopathogenesis of rosacea. It details the composition of 0.75% Rosex cream used to treat rosacea and the mechanism of its action. The results of treatment in 22 patients are given.

The paper considers the autoimmune (immune) theory of vitiligo pathogenesis. Based on this theory, the author analyzes the results of treating 52 vitiligo patients with the immunomodulator neovir.

The authors analyze the structure of sarcoidosis morbidity on the basis of clinicomorphological monitoring of patients with different forms from Moscow and the Moscow region. They consider the specific features of the morpho- and immunogenesis of granulomatous inflammation in sarcoidosis, which result in a significant fibrotic process and evolving cosmetic defects. The clinical efficacy of Egallohit (as cream and gel) has been evaluated in 35 patients with sarcoidosis of the skin. The paper shows the efficacy of the agent and provides evidence that it is expedient to include it into cutaneous sarcoidosis treatment regimens to prevent the fibrotic processes leading to the development of cosmetic defects.

The responsiveness of the lower extremity microcirculatory bed was determined in 62 patients with onychomycosis with comorbidity via duplex scanning of the interphalangeal arteries of the first toe. After load testing, 52 patients were found to have the ultrasound signs of hemodynamic disorders, which were characterized by an increase in the minimal diastolic rate and a reduction in the resistive index.Microcirculatory disorders are common in prolonged fungal infection and generally in the involvement of 2-3 nail plates as the hypertrophic type concurrent with foot mycosis. Addition of angioprotectors to multicomponent therapy yields better results of treatment in a larger number of patients.

The paper describes a clinical case of smooth skin microsporia with unusual symptomatology in an 8-year-old child as a result of misdiagnosis of this mycosis.

The paper discusses the clinical and diagnostic features of primary syphilis with hard chancre being located in the cervix uteri. The authors note that consideration of the clinical features of primary syphiloma, alertness to possible specific lesion of the cervix uteri in syphilis, and, accordingly, timely laboratory testing for syphilis allows diagnostic errors to be avoided.

The data available in the literature suggest that in the past decades visceral involvements in syphilis, which result in death, have become a rarity. The present paper analyzes a clinical case of syphilitic involvement of the pulmonary and cardiovascular systems with a fatal outcome, which was diagnosed postmortem, only at the patient's autopsy.

The paper provides the results of an anonymous questionnaire in 77 pediatric dermatovenereologists and 96 parents of children with dermatoses. The main legal problems arising from dermatologist-child-parent relationships have been revealed.

The paper presents the current information on the mechanisms of damaging action of ultraviolet irradiation on the skin, shows the basic differences of photoaging (PA) from natural skin aging. Particular emphasis is placed on the problem of suntan in the solaria. The methods for the prevention and treatment of PA are also described.

The paper describes a case of corkscrew hair, a rare hair abnormality, in a patient with pathology of the liver and digestive tract.