The domestic tranquilizer mebicar attracted our attention. Previously, this drug was found to have antihypoxic, analgesic, stress-protective, and antiarrhythmic properties. This combination of effects can be very valuable in the treatment of patients with coronary heart disease. This paper evaluates the effectiveness of mebicar in the treatment of patients with angina pectoris; based on the results of a study by one of the authors, an experimental substantiation of the antianginal action of the drug is given.

The aim of the present work was to study in dynamics the concentration of connective tissue metabolites (free and peptide-bound oxyproline) in patients with myocardial infarction at different stages of in-hospital rehabilitation when using metabolic agents as part of complex therapy: free crystalline amino acid solution - alvesin-nova (GDR) in combination with the anabolic steroid retabolol.

Relatively late complications resulting from long-term smoking are well known, both from the lungs (chronic bronchitis, emphysema, lung cancer) and the cardiovascular system (atherosclerosis, coronary heart disease, arterial hypertension, etc.). We studied right ventricular contractility in young smokers. We observed 33 smokers aged 18 to 30 years and 35 age-matched healthy nonsmokers. All 68 subjects underwent complete clinical, laboratory and instrumental examination in a therapeutic clinic.

As for most systemic connective tissue diseases, in rheumatoid arthritis the questions of etiology have not yet been resolved; therefore, pathogenetic therapy is considered to be reasonable. Since inflammation is the most constant clinical and anatomical manifestation of rheumatic diseases, the anti-inflammatory effect can be generalized as the main goal of anti-rheumatic treatment.

The purpose of this work was to clinically evaluate the efficacy of lithium electrophoresis in some thyroid diseases. We examined 28 patients with primary toxic diffuse goiter aged from 20 to 54 years (2 men and 26 women). Seventeen patients had mild thyrotoxicosis, nine had moderate, and two had severe thyrotoxicosis. Diffuse increase of thyroid gland of I-II degree was found in 22 patients, III - in 6 patients. thyrogenic ophthalmopathy of I-II degree was observed in 6 patients. Conservative antithyroid therapy was required in 23 patients, and 5 patients underwent strumulectomy.

The aim of the present study was a comparative analysis of blood pressure in mesenteric and intraorgan vessels and cardiac hemodynamic parameters in different types of general and epidural anesthesia, peritonitis, traumatic shock, internal bleeding and intestinal infarction.

Trigeminal neuralgia is one of the most severe and common forms of facial pain syndrome. Its etiology is varied. Most researchers characterize trigeminal neuralgia as a complex process in which the focus of irritation in the afferent part of the nerve causes changes in the stem and subcortical structures in the form of foci of pathological activity manifested by paroxysms.

One of the most urgent problems of modern obstetrics is the weakness of uterine contractile activity. Its frequency ranges from 1.6 to 22.2%, averaging 10%. This pathology significantly increases the number of surgical interventions, dramatically increases the risk of fetal hypoxia, purulent-septic diseases in the mother and the newborn. Perinatal mortality increases. We present the materials of clinical observations for 111 women treated with obzidan.

Comprehensive anti-inflammatory treatment with intracutaneous antibiotic injection was performed in 20 patients under 30 years of age with acute inflammatory diseases of the appendages of the uterus. On admission, nine women were diagnosed with acute pelvio-peritonitis, six - with acute metoendometritis and bilateral salpingo-oophoritis, two - with acute purulent salpingo-oophoritis, two - with posterolateral parametritis and one - with diffuse peritonitis. Three women were admitted on the first day of the onset of the disease, the remaining 17 were admitted in the first 5 days.

The study of neurohormonal-visceral relationships in patients with uterine endometriosis is of practical significance in the development of rational therapy and prevention of this complex and rather frequent pathology. This study was aimed to investigate the functional state of the digestive glands of the stomach, intestines, liver and pancreas in 152 patients with uterine internal endometriosis (Group 1) and in 50 patients with recurrent endometrial hyperplasia (Group 2). Twenty healthy women were the control group. Patients with no history of diseases of the digestive system were selected for the examination.

The aim of this work was to study some indices of immunological reactivity in newborns with intrauterine hypotrophy of different genesis and peculiarities of their development during the first year of life. For this purpose, in 141 newborn infants with intrauterine hypotrophy (treatment group) and in 28 normotrophic children (control group) the general state at birth and the peculiarities of the adaptation period were evaluated. In 54 of them the immunoglobulin spectrum of blood serum, the level of circulating immune complexes and individual components of kininin system were studied.

Infectious and allergic bronchial asthma occurs on the basis of inflammatory diseases: acute and chronic pneumonia, influenza, bronchitis, pathology of ENT organs. Bacteria, toxins, decay products of own tissues cause sensitization process and subsequent allergic reaction, which is localized in the tissues of the bronchial tree, involves primarily the peripheral structures of the autonomic nervous system and can cause increased excitability of the parasympathetic department.

The aim of this study was to compare the state of nonspecific resistance, cellular and humoral immunity in young children with acute respiratory infections with a smooth course, with the first episode of bronchoobstructive syndrome (BOS) and with recurrence of this syndrome.

We examined 70 patients with metabolic nephropathy (51 with oxaluria predominance, 19 with uric acid metabolism disorders). Distribution of patients into groups was carried out according to the results of multistage research, including analysis of pedigree; repeated biochemical studies, clinical and radiological comparisons. Endogenous creatinine clearance, residual nitrogen level, urea in blood, acid-base balance were determined to characterize the functional state of the kidneys. Renal tubular function was assessed by urinary excretion of calcium, phosphates, amino acids, titratable acids, Zimnitsky's test. To detect metabolic disorders we studied uric acid content in blood and urine, oxalic acid and xanthurenic acid content in daily urine.

We followed up 61 children with urate nephropathies. Of them there were 34 children aged from 1 to 7 years, from 8 to 14 years - 27. Dysmetabolic nephropathy proper, characterized by minimal clinical and laboratory manifestations, was diagnosed in 13 patients, interstitial nephritis of dysmetabolic genesis - in 18, secondary pyelonephritis developed against the background of disturbed purine metabolism - in 30, pyelonephritis due to urolithiasis - in 3.

The aim of the present work was, first, to clarify the question of which part of factor XIIa is formed in blood plasma by the reciprocal mechanism (reactions 1, 2); second, it was required to determine which of the two agents - factor XIIa inhibitor from corn or kallikrein inhibitor contrical - was more effective for inhibition of factor XII and precallikrein activation at the contact surface. A pool of platelet-poor citrate plasma obtained from donor blood was used in the experiments. In order to reduce contact activation of blood, fluoroplastic dishes and plastic dispensers were used when obtaining, processing, and storing it.

Pickwick's syndrome is characterized by marked obesity, somnolence (daytime), intermittent breathing during night sleep, cyanosis, polycythemia, right ventricular hypertrophy, shortness of breath, decreased minute respiratory volume, alveolar ventilation volume, blood oxygen saturation, hypercapnia, right ventricular failure. In this disease there is so-called exogenous alimentary obesity with predominant deposition of fat in the subcutaneous tissue of the anterior abdominal wall.

When studying the auditory function of patients suffering from unilateral chronic purulent otitis media for a long time, we noticed that along with hearing reduction in the diseased ear of the mixed type, there was often hearing reduction in the opposite ear of the neurosensory hearing loss type. These changes were even more pronounced when chronic purulent otitis media was combined with labyrinthitis. In patients aged 50 years and older, hearing loss in the opposite ear, exceeding age thresholds, was more frequent.

Hypothalamic pubertal syndrome is a common disease of adolescence and adolescence that occurs during the period of physical status and personality formation. It is characterized by interstitial brain damage and hypothalamic-pituitary-endocrine dysregulation (hypercorticism, hyperaldosteronism, hyperprolactinemia, gonadotropin production disorders). Often this syndrome limits the fitness of young men and women for some professions requiring physical and emotional stress, in particular for military service.

Available data in the literature on the body's reactions to drugs in hypertension in the experiment and in clinic concern means of both pathogenetic therapy (hypotensive, antispasmodic, sedative, etc.), and those drugs, the use of which against the background of hypertension is possible for concomitant diseases.

The aim of the present study was to evaluate the effect of a single dose of nitroglycerin and obzidan on myocardial contractility by hemodynamic indices in patients with various forms of coronary heart disease.

In order to prevent complications in the department of anesthesiology and intensive care, we conducted a clinical trial of the above drug as a local antiseptic agent for fixation of the catheter located in the subclavian vein. Two identical groups of patients from different departments were formed by random sampling: neurosurgical, surgical, traumatological, pediatric surgery, ENT, and maxillofacial surgery. Group 1 consisted of 177 patients in whom the drug Lifusol was used for catheterization of the subclavian vein; 187 patients in Group 2 received catheter fixation by the usual method using adhesive plaster.

We performed a course of treatment with the helium-neon laser L G-75 in the conditions of a polyclinic for patients with bronchial asthma (170 persons) and chronic obstructive bronchitis (90). Exposure to the laser beam was made taking into account the experience of reflexotherapy. Time of exposure to each biologically active point was 10 s with irradiation power of 25 mW (course - 15-20 procedures).

In the pathogenesis of scleroderma an essential role is played by intensive collagen biosynthesis, which causes the development of fibrotic-sclerotic lesions. In this connection, it is pathogenetically substantiated the use of agents, the effect of which is aimed at decreasing the synthesis and increasing the catabolism of collagen.

In this work we studied the possibilities of the unloading perimetric test depending on the glaucoma stage and the degree of visual field expansion along the meridians during the test.

We performed 37 hemosorption sessions in 16 patients (7 men, 9 women) with acute inflammatory kidney diseases, 10 of them - in combination with hemodialysis. The patients ranged in age from 21 to 62 years. The disease was caused by impaired urodynamics and highly pathogenic microflora.

Toxocarosis is a tissue helminthiasis of zoonotic nature. The disease is caused by permanent migration of canine and feline ascarid larvae in human internal organs and is accompanied by high eosinophilia. Parasite larvae do not adapt to the human body, never reach a mature stage, migrate very long, entering various organs and tissues with the formation of specific eosinophilic granulomas and vasculitis of allergic nature in them.

A cumulative examination of 4,070 schoolchildren aged 7 to 14 years was conducted in Kazan. Symptoms of digestive tract lesions were found in 340 children. In addition to these patients 290 children with a history of gastroenterological risk factors were identified. Parents had gastroenterological diseases in 40% of those examined, 63% had chronic foci of infection, and 36.9% had acute gastrointestinal and parasitic diseases.

We studied the content of chondroitinseric acid, glucuronic acid, hexosamines, fucose, and N-acetylneuraminic acid, as well as the activity of trypsin-like proteases in the papule tissues (biopsied skin from the lesion focus, including papillary layer of derma, basal and thorny layers of epidermis) and in parakeratotic scales of 104 psoriasis patients (53 of them were diagnosed with progressing stage, 37 with stabilizing stage, 14 with regressing stage).

The prevention of alcoholism must begin with eradicating the alcoholism that causes it, but alcoholics should not be identified with drunkards. Drunkenness is systematic, immoderate consumption of alcoholic beverages, moral and ethical promiscuity with a loss of control over one's behavior and actions with certain social consequences; alcoholism is a disease.

The high prevalence and progressive course of periodontal disease dictate the need for dispensary monitoring of these patients. We have more than 10 years of experience in specialized treatment of this category of patients. The work in the periodontal office is performed by two specially trained doctors and a nurse. Patients undergo laboratory and X-ray examinations, receive treatment, and there is also a patient record book.

Blood plasma fibronectin is a glycoprotein with a molecular weight of 450 kD consisting of two almost identical polypeptide chains linked by disulfide bonds. The normal concentration of fibronectin in adult plasma is 0.3-0.4 g/l. Plasma fibronectin is synthesized by hepatocytes and possibly by endothelial cells. In its chemical structure and immunological properties it is similar to tissue fibronectin, which is formed mainly by connective tissue cells and is a part of extracellular matrix and collagen fibers.

Advances in pharmacy, pharmacology in recent years and the rapid development of the chemical-pharmaceutical industry have significantly expanded the arsenal of drugs used, the number of which continues to increase. With the introduction into practice of new drugs, the possibilities of etiotropic and pathogenetic therapy have increased. However, at the same time as the effectiveness of drug therapy has increased, it has become less safe. In recent years, cases of drug-induced side effects, which often exceed the severity of the underlying disease, have increased.