The data on the clinical picture of drug allergic reactions occurring in dental practice are systematized, and, taking into account them, reasonable recommendations are proposed for the diagnosis, treatment and prevention of allergic reactions manifested on the oral mucosa and outside the mouth when drugs are introduced into the body in various ways.

In the clinic and in the experiment, the influence of disturbances in the functional state of the salivary gland on the development of dental caries was studied.

Based on a survey of 1037 children and adolescents, it was found that in children who have consumed water rich in fluoride throughout their lives, the periodontium is more resistant than in children who use fluorine deficient water.

Due to the fact that the supply of the body with ascorbic acid in various forms of periodontal disease has not been studied enough, in the clinic it is usually used in the treatment of periodontal disease without taking into account the form and degree of the pathological process.

The results of correcting malocclusion by the method of R. Frenkel in 209 patients aged 6 to 16 years have been analyzed. Based on the study of 836 diagnostic models of their jaws and 254 lateral teleradiograms of the head obtained before and after orthodontic treatment, it was concluded that the success of therapy is due to the simultaneous elimination of morphological and functional disorders by using function regulators of I, II and III types during periods of active growth of the jaws.

Twelve years of observations of persons who have used removable dentures with internal clasps indicate that this design of dentures provides a sufficient functional result and a good cosmetic effect.

Studies carried out in 107 patients with acute and chronic odontogenic osteomyelitis of the jaws found that during these processes there is a decrease in salivary cholinesterase activity and an increase in erythrocyte cholinesterase activity.

A method of surgical treatment of fractures of the mandibular angle, which provides a good functional result, has been proposed. Due to its ease of implementation, it can be used on an outpatient basis.

Seven endoscopic polypectomies of the duodenal bulb were performed. It is recommended to perform this operation in a surgical hospital after preliminary histological examination of the biopsy material.

In 100 children with biliary pathology, the condition of the mucous membrane of the esophagus, stomach and duodenum was studied using a gastroduodenofibroscope.

According to the authors, in order to establish the cause of jaundice, if the conservative treatment is ineffective, diagnostic laparotomy with revision of the biliary tract is justified. Such an intervention, even in those suffering from Botkin's disease, as shown by observations (12), does not cause dangerous complications. It can contribute to a more favorable course of the underlying disease.

308 people were examined for peritoneal adhesive disease, of which 208 - according to the generally accepted method and 100 - with a comprehensive clinical X-ray examination, including multi-projection fluoroscopy with the study of mucosal relief, polygraphy, double and triple contrast, the use of pharmacological drugs (aeron, atropine), dynamic monitoring the evacuation function of the gastrointestinal tract.

In order to prevent postoperative functional obstruction, a method of temporary minimal gastrostomy with the use of the round ligament of the liver was developed and tested during surgery on the biliary tract (in 41 patients).

The failure of the duodenal stump is more common after operations for peptic ulcer disease. Its occurrence is associated with significant technical difficulties during the formation of the stump during the operation.

The angioarchitectonics of the blind and terminal ileum and vermiform appendix was studied using the transillumination technique during 69 operations, on 12 resected preparations and 67 autopsy organocomplexes. Blood pressure was measured in the intramural vessels of the ileum (43), the blind (43), and the appendix (35). The obtained data allow us to recommend transillumination and determination of blood pressure in intramural vessels as additional research methods during surgery.

As shown by clinical and pathological studies, a significant number of patients with peptic ulcer disease, especially over the age of 50 (up to 27%), have chronic pathological changes in the liver tissue that require correction before and after surgical treatment.

The blood pressure in the intramural vessels of the submucosal layer of the intestine and stomach was investigated during surgery in patients using an original non-injection method. With hyper- and hypotension, both equidirectional and so on were revealed and multidirectional shifts in regional and systemic blood pressure.

The case histories of 326 patients with acute pancreatitis were analyzed. Some features of various forms of pancreatitis and their frequency are noted, data on the most typical and rare symptoms are summarized.

As a result of studying the blood vessels of the pancreas in elderly and senile people (150 observations), their atherosclerotic lesion was established, which develops simultaneously with fibrotic changes in the parenchyma. In the light of these data, the mechanism of development of necrotic organ changes in acute pancreatitis becomes clear.

Out of 99 patients operated on for destructive forms of acute pancreatitis, 12 in the postoperative period developed complications: fistulas of the gastrointestinal tract, arrosive bleeding, phlegmon of the retroperitoneal space, abscesses of the small pelvis and subphrenic space. Most often, purulent parapancreatitis led to the development of these complications.

The long-term outcomes of treatment of 230 patients with chronic pancreatitis were studied. Indications for surgical and conservative treatment have been developed. An early pathogenetically grounded operation, as a rule, gave good and satisfactory results.

Abstract. The functional state of the stomach, pancreas and liver was studied in 105 patients with diabetes mellitus. In 52.4% of them, combined disturbances in the activity of the main digestive glands were revealed, in 38% a decrease in the secretory and acid-forming functions of the stomach was combined with the phenomena of complete dyspancreatism and with a decrease in the antitoxic and protein-forming functions of the liver.

The study involved 185 patients with diabetes mellitus aged 17 to 60 years, as well as 88 people who made up the control group. In men, diabetes mellitus has no significant effect on the occurrence of coronary atherosclerosis, as evidenced by the absence of a difference in the frequency of detection of coronary insufficiency in patients with diabetes mellitus and in the control group.

Studies carried out in 138 patients with stage II ischemic heart disease revealed an increase in serum insulin in 70% of them. A close relationship was also found between hyperinsulinemia and hyperlipemia.

The prospects of applying the methods of biophysical study of blood corpuscles for the diagnosis of early stages of myocardial infarction are shown. The analyzed tests make it possible to differentiate myocardial infarction from cardialgias of other genesis.

334 patients with lung cancer (most of them advanced) were treated, 81 of them with thiophosphamide (group 1), 159 with it in combination with calcium salts, vitamin D2 and fish oil (group 2) and 94 - means of symptomatic therapy (control group).

The results of laboratory and clinical studies of blood serum by the polarography method in patients with tumors of the genitals and in practically healthy women are presented. There was a difference in the height of both waves of the polarogram, depending on the nature of the process (benign or malignant).

The study of the function of external respiration in pregnant women with arterial hypotension showed that differentiated physiopsychoprophylactic preparation for childbirth helps to increase the functional capabilities of the external respiration system.

The results of complex treatment with carbogen in 91 patients with retinal and optic nerve diseases are presented. The majority of patients improved visual function - visual acuity improved in 60%, the field of vision expanded in 42%.

In 384 patients with predominantly allergic dermatoses, specific hyposensitization was performed with standard purified allergens of hemolytic staphylococcus and hemolytic streptococcus produced by Kazan Research Institute of Epidemiology and Microbiology.

An extensive clinical material on the use of dimethyl sulfoxide (DMSO) in dermatology has been analyzed. Both the "conductive" and the actual therapeutic efficacy of the drug were noted.

The modern possibilities of pharmacotherapy of chronic gastritis are considered. The specific and nonspecific (pharmacodynamic) effect of vitamins, stimulators of physiological and reparative regeneration processes, the so-called substitution therapy, dosage forms affecting secretory-motor disorders, steroid hormones (glucocorticoids and steranabols), symptomatic agents are highlighted.

Modern possibilities of intravital study of the intestinal mucosa give reason to revise the traditional concepts in the issues of differential diagnosis of pathological processes in the large intestine. In some cases, taking into account the dynamics of clinical and morphological changes, instead of the diagnosis "chronic colitis" it is more legitimate to use the term "restructuring colitis" or "collective farm".

The issues of classification of peptic ulcer are discussed. When constructing a diagnosis, it is proposed to take into account the localization of the ulcer, its stage (fresh, cicatricial, non-scarring) with the release of the pre-ulcer state, the phase of peptic ulcer disease (exacerbation, remission), its form (uncomplicated and complicated) and course (rarely, often and continuously recurrent), and also some functional indicators (secretory and motor functions of the stomach) and the state of general nutrition.

The study of the basal level of gastrin in the blood and stimulation of its secretion with insulin in patients with peptic ulcer disease revealed certain changes in its content depending on the localization of the ulcer and the form of the clinical course of the disease.

We have treated 30 patients with gastric ulcer and duodenal ulcer with severe and moderate severity with specific inhibitors of kininforming enzymes - trasilol, counterkal, gordox and a specific bradykinin antagonist - prodectin.

We have studied the diagnostic value of some clinical symptoms of peri-root cysts of various localization. As a result of clinical and radiological observations of the course of 436 peri-root cysts and analysis of their symptoms, the peculiarities of their manifestation depending on localization were established.

When analyzing 22,054 large-frame chest fluorograms in anterior frontal projection, we revealed the presence of an additional lobe of the azygos vein in 59 people — 35 men and 24 women.

We carried out a bacteriological study of the effusion from the abdominal cavity found during appendectomy in 192 patients. In 33 of them the exudate was serous, in 98 it was serous-purulent and in 61 it was purulent.

Damage to the pancreas presents great difficulties for diagnosis, as a result of which the mortality rate in them ranges from 12 to 43.5% (A.V.Belsky).

Lumbar hernias are rare. It is known that they leave the abdominal cavity through its wall in the weakest places, which are the Grünfeld-Lesgaft triangle and the Petit triangle.

Pregnancy in the rudimentary horn of the uterus is a rare form of pathology. Termination of pregnancy always occurs as an external rupture of the fetus and is accompanied by profuse bleeding, dangerous for a woman's life.

We used therapeutic electroanesthesia in the stage of analgesia in 30 patients with algomenorrhea (17 with primary and 13 with secondary) aged 16 to 32 years. The duration of the disease was from 5 months. up to 3 years. All women noted pain in the lower abdomen and in the lower back 1-2 days before menstruation or in the first 1-2 days of menstruation against the background of vegetative disorders (nausea, vomiting, pain in the epigastric region, headaches, fainting, sweating, etc.).

Sturmdorf cervical amputation is considered in gynecological practice as an operation used to prevent cervical cancer.

Mesonephroma (synonyms: urogenital mesoblastoma, hypernephroid, clear cell adenocarcinoma, mesonephrogenic cancer, etc.) is a dysontogenetic formation arising from the remnants of the embryonic mesonephros

A methodology is proposed, with the help of which the selection of the contingent of persons subject to dispensary observation is carried out.

1199 samples of atmospheric air were analyzed for the content of sulfur dioxide, sulfuric acid mist, nitrogen dioxide in the industrial area of the city. Air pollution has become much lower than in 1957-1966, but the total concentration still exceeds the permissible value.

The maximum permissible dose of chromium in the daily diet of a person is proposed for inclusion in the formula of a balanced diet - 3 μg per kg of body weight.

The monograph is devoted to a complex and poorly studied issue of clinical medicine. It is based on the author's observations of 580 patients. The book consists of two sections - general and special.

March 1978 marked the 70th anniversary of his birth and 45 years of medical, scientific, pedagogical and social activities of the Honored Scientist of the RSFSR and TASSR, Doctor of Medical Sciences, Professor Midhat Kharisovich Faizullin.