The desire to clarify the dark question of the origin of tumors gave rise to numerous attempts to experimentally reproduce tumors. One of these attempts is represented by the experiments of Fischer's, (1906) with the reproduction of atypical epithelial growths on the ear of a rabbit using the injection of Scharlachrot and Sudan III into olives. oil.

As in 1907, Myriyeg and Dossman discovered a new property of blood serum to inhibit the proteolytic action of leukocytes and trypsin, so to speak, the antiproteolytic, or antitripsic property of blood serum, the latter underwent numerous observed directions. Studies, especially of the late time, have established both the amount of this anti-body in the blood of normal people, and its fluctuations in various pathological states of the body. At the same time, it turned out that from all painful processes with the greatest constancy of an increase in antitrypsin, the blood of cancer patients possessed the greatest constancy.

M.G. and M.G. The question of a thyroid gland transplant arose soon after the discoveries of Ord (1880), replacing the absence of a thyroid gland in myxedemic patients at autopsy, a neuropathologist Weiss (1880), who indicated that after total extirpation of the thyroid gland, convulsions appear, called by him tetany, Reverdin (1882) and Kocher (1883), who firmly established that complete removal of the thyroid gland leads to sharp changes in both the mental and the physical organism. He called this disease Renegdin “myxedema postoperatorie”, and Kocher “cachexia strumipriva.” They also pointed out that cretinism depends on the absence of a thyroid gland.

In 1861, Pirogov publishes an extensive and instructive article “About the charter of the new gymnasium, proposed by the project for the transformation of Marine educational institutions” in the "Morskom Collection".