Aim. To study the possibility of using and estimate the efficiency of a new tablet form of biologically active supplement in patients with vegetovascular dystonia syndrome.

Materials and methods. One hundred patients with vegetovascular dystonia syndrome, including 50 patients of the main group and 50 patients of the control group were examined. There is presented the composition of prescription formula of biologically active supplement, based on participation of its components in the correction of disturbed metabolic processes of the nervous system.

Results. Additional application of biologically active supplement in combination with drug significantly improves cerebral blood flow, decreases blood viscosity and risk of cellular membrane impairment, normalizes arterial pressure, elevates initiative and attention, reduces headache in patients of the main group with vegetovascular dystonia syndrome.

Conclusions. Use of biologically active supplement has a positive effect in complex therapy of patients with vegetovascular dystonia syndrome.

The pathology of carotid arteries takes a significant place in the structure of cerebral vascular diseases. The review of literature on pathologic tortuosity of carotid arteries is presented in the paper; the influence of this state on cerebral circulation disturbance is discussed; the etiology, diagnosis and methods of treatment of pathologic deformity of magistral arteries of the head are considered.

Aim. To reveal the changes in the quality of life among young men with visceral obesity depending on androgen deficiency manifestation.

Materials and methods. Examination of 80 men with the mean age of 45.5 ± 7.7 years with abdominal type of obesity was carried out. The total blood serum testosterone level was determined in all patients and their life quality was assessed using SF-36 health survey.

Results. In the examined group, 72.3 % of patients had statistically significant (p = 0.03) testosterone deficiency, and their life quality indices were characterized by lower scores of social functioning (SF) and psychological component of health compared to the group of persons with normal testosterone level.

Conclusions. In most men with abdominal obesity, there was observed androgen deficiency that leads to significant limitation of social contacts, decrease in communication level, caused by impairment of physical and emotional status. Therefore, normal testosterone level is required to support good physical and mental health in men.

The factors, influencing the development of cognitive defects in patients after chemotherapy are the following: personal individual intellectual and genetic characteristics, immune dysfunction and neurotoxicity. Cognitive domains, disturbed to a greater extent, are memory, attention, thinking rate and executive functions. Sixty one patients, diagnosed lymphoproliferative disease, (chronic lympholeukosis – 28 persons, multiple myeloma – 33) were examined; patients’ mean age was 63.87 ± 9.76 years. Reduced cognitive function was revealed in 73.77 % of patients, a mean score by MoCA scale was 22.87 ± 4.08. Cognitive defects negatively influence patients’ quality of life, significantly reduce their physical and mental working ability, everyday activity, make execution of professional duties difficult, besides they can complicate nursing.

Aim. To characterize the inflammatory process in gastric mucosa among adolescents with chronic gastritis in different variants of its bacterioviral infection.

Materials and methods.Clinicoanamnestic, laboratory, endoscopic and morphological examination of 200 adolescents (age range 12–18 years) with chronic gastritis was carried out. In all patients, clinicoanamnestic data, standard laboratory study, esophagogastroduodenoscopy, gastrobiopsy followed by morphological analysis with visual analogue scale were assessed. According to the results of examination, all adolescents were divided into 4 groups depending on the character of bacterioviral infection of gastric mucosa.

Results. No statistically significant differences were detected while comparing the rate of clinical manifestations of pain abdominal, dyspeptic, intoxication and asthenovegetative syndromes as well as changes, revealed in laboratory and ultrasound studies in the above mentioned groups of adolescents. Maximal presentation of macroscopic and pathohistological changes was registered in patients of group 4 (association between colonization of GM with highly pathogenic Hp strains and EBV persistence).

Conclusions. The character of bacterioviral infection of gastric mucosa significantly determines the manifestation degree and activity of inflammatory process. The least degree of manifestation and activity of inflammatory process is registered when mucosa is colonized by low pathogenic Hp strains. Maximal presentation of macroscopic and pathohistological changes in the gastric mucosa is registered in adolescents with associated infection by high pathogenic Hp strains and Epstein-Barr virus. It is manifested by domination of marked and highly active inflammation and appearance of the signs of mucosal atrophy of gastric body and antrum.

Aim. To analyze the demographic indices in connection with aging of the population in Perm Krai and the Russian Federation and as a result – to single out problems and ways of solution.

Materials and methods. Calculation and dynamic analysis of reproduction of the population in Perm Krai and the Russian Federation over the period of 2005 – 2017 was performed using official statistic data in connection with gender-and-age-specific characterization of the population.

Results. The processes of aging of the population were estimated from demographic positions. Socioeconomic problems, associated with them, were singled out, the ways of their solving were determined in accordance with national projects regarding health and health care.

Conclusions. At the expense of growing index of expected average life, decrease in fertility and birth rate there is observed accumulation of older age groups of the population, i.e. process of aging. It, naturally, results in growth of chronic pathology, mortality not only in the older age periods but also in the able-bodied part of the population, thus, reducing working potential.

Cerebral amyloid angiopathy, associated with inflammation (CAA-I) is a rare syndrome, described rather long ago. The course of disease varies from conditionally asymptomatic, very seldom diagnosed forms to severe lethal cases with intracerebral bleedings and brain edema. The basic clinical symptoms of CAA-I are cognitive disorders, convulsions, headache, consciousness impairment, often ignored or wrong interpreted. Manifestations of CAA-I are a part of clinicoradiological continuum, significantly influencing the course of other cerebrovascular diseases. The paper presents description of a clinical case of symptom-free or preclinical form of CAA-I, incidentally detected while realizing magnetic resonance tomography. Analysis of this clinical case and literature data demonstrates difficulties of CAA-I differential diagnosis, value of neurovisualization in patients with cognitive disorders and accentuates the need of expanding the existing diagnostic criteria of CAA-I.

The paper deals with historical information on the formation and development of the Department of Therapeutic Stomatology of Academician Ye. A Vagner Perm State Medical University – “Alma-mater” for several generations of dentists. It is the history not only in figures and factors but regards people, who contributed to the development of native stomatology in the Ural region.

The paper presents a detailed analysis of global trends and subtrends of modern conservative-and-preventive stomatology, based on survey-analytical methods of study in interconnection with performed earlier, realized nowadays and planned scientific and practical elaborations of Perm therapeutists-stomatologists school.