An informationtized, digitalized, and intelligent emergency response mode is currently required in China to address the weaknesses and low efficiency in public health emergency management in the aspects of quick response mechanism, multi-department collaboration, and information interaction; this new mode can promote the response capabilities of China’s public security sector. A descriptive research method is adopted to analyze the status quo of public health emergency response systems and intelligent emergency response development in other countries, and summarize the requirements, current status, and main problems of health emergency management in China. The development goals, major research tasks, and technological approaches are further proposed. To develop a preventative public health emergency response network in China, we suggest that a major national biological monitoring and early-warning project should be established for health emergency response, relevant laws and regulations promulgated and revised, data integration and sustainable development of the emergency management mechanism maintained, an intelligent health emergency response industry encouraged, and professionals for medical care and preventative medicine integrated.