Problems in China’s agricultural resources and environment have become increasingly prominent, with distinct resource and environment constraints for regional agricultures. Based on regional differentiation in agricultural resource and environment characteristics, this paper divided the country into 10 first-level zones and 57 second-level zones at the county scale. The first-level zones were divided according to regional differentiation in climate and geotectonic. And the second-level zones differentiate in water resources, land resources, and environmental conditions. It analyzed the agricultural production conditions, types of resources and their different combinations, environmental production conditions, and existing problems in these zones. This study proposed the strategies of “optimizing the spatial layout of eastern, central, and western regions” and “improving Northeast China, regulating North China, and recovering South China”. Twenty-seven second-level zones, undertaking the supply of major agricultural products in China, were identified and labeled as “major agricultural developing regions in China”. The development direction and construction measures of the major agricultural developing regions in China were suggested to maintain and improve the health and sustainability of China’s agricultural production system.