%A Qingjun Liu, Zhongjie Sun, Ligong Chen %T Memory T cells: strategies for optimizing tumor immunotherapy %0 Journal Article %D %J Protein Cell %J Protein & Cell %@ 1674-800X %R 10.1007/s13238-020-00707-9 %P 549-564 %V %N %U {https://journal.hep.com.cn/pac/EN/10.1007/s13238-020-00707-9 %8 %X

Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.