%A Dengwen Li, Songbo Xie, Yuan Ren, Lihong Huo, Jinmin Gao, Dandan Cui, Min Liu, Jun Zhou %T Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner %0 Journal Article %D 2011 %J Protein Cell %J Protein & Cell %@ 1674-800X %R 10.1007/s13238-011-1015-4 %P 150-160 %V 2 %N 2 %U {https://journal.hep.com.cn/pac/EN/10.1007/s13238-011-1015-4 %8 2011-02-01 %X
Angiogenesis, a process by which the preexisting blood vasculature gives rise to new capillary vessels, is associated with a variety of physiologic and pathologic conditions. However, the molecular mechanism underlying this important process remains poorly understood. Here we show that histone deacetylase 6 (HDAC6), a microtubule-associated enzyme critical for cell motility, contributes to angiogenesis by regulating the polarization and migration of vascular endothelial cells. Inhibition of HDAC6 activity impairs the formation of new blood vessels in chick embryos and in angioreactors implanted in mice. The requirement for HDAC6 in angiogenesis is corroborated