%A Liping Deng,Ruotong Ren,Jun Wu,Keiichiro Suzuki,Juan Carlos Izpisua Belmote,Guang-Hui Liu %T CRISPR/Cas9 and TALE: beyond cut and paste %0 Journal Article %D 2015 %J Protein Cell %J Protein & Cell %@ 1674-800X %R 10.1007/s13238-015-0137-5 %P 157-159 %V 6 %N 3 %U {https://journal.hep.com.cn/pac/EN/10.1007/s13238-015-0137-5 %8 2015-04-01 %X

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.