Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis
Accepted date: 25 Jul 2022
Copyright
Gang Xu , Li-na Qi , Mei-qing Zhang , Xue-yun Li , Jin-long Chai , Zhi-qing Zhang , Xia Chen , Qian Wang , Ke-ran Li , Cong Cao . Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis[J]. Protein & Cell, 2023 , 14(3) : 217 -222 . DOI: 10.1093/procel/pwac035
1 |
Aoki M , Mieda M , Ikeda T et al. R-spondin3 is required for mouse placental development. Dev Biol 2007; 301: 218- 226.
|
2 |
Bai JY , Li Y , Xue GH et al. Requirement of Galphai1 and Galphai3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response. Theranostics 2021; 11: 4894- 4909.
|
3 |
Bian ZJ , Shan HJ , Zhu YR et al. Identification of Galphai3 as a promising target for osteosarcoma treatment. Int J Biol Sci 2022; 18: 1508- 1520.
|
4 |
Cao C , Huang X , Han Y et al. Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the AktmTORC1 pathway. Sci Signal 2009; 2: ra17.
|
5 |
Chen Z , Zhang J , Yuan A et al. R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells. Am J Physiol Cell Physiol 2020; 318: C664- 674.
|
6 |
Gu H , Tu H , Liu L et al. RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer. Ann Transl Med 2020; 8: 1351.
|
7 |
Jin YR , Yoon JK . The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol 2012; 44: 2278- 2287.
|
8 |
Kazanskaya O , Ohkawara B , Heroult M et al. The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development 2008; 135: 3655- 3664.
|
9 |
Liu YY , Chen MB , Cheng L et al. microRNA-200a downregulation in human glioma leads to Galphai1 over-expression, Akt activation, and cell proliferation. Oncogene 2018; 37: 2890- 2902.
|
10 |
Marshall J , Zhou XZ , Chen G et al. Antidepression action of BDNF requires and is mimicked by Galphai1/3 expression in the hippocampus. Proc Natl Acad Sci USA 2018; 115: E3549- 3558.
|
11 |
Sun J , Huang W , Yang SF et al. Galphai1 and Galphai3mediate VEGFinduced VEGFR2 endocytosis, signaling and angiogenesis. Theranostics 2018; 8: 4695- 4709.
|
12 |
Tocci JM , Felcher CM , Garcia Sola ME et al. R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development. IUBMB Life 2020; 72: 1546- 1559.
|
13 |
Wang Y , Liu YY , Chen MB et al. Neuronal-driven glioma growth requires Galphai1 and Galphai3. Theranostics 2021; 11: 8535- 8549.
|
14 |
Yao J , Wu XY , Yu Q et al. The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo. Sci Adv 2022; 8: eabn6928.
|
15 |
Zhang YM , Zhang ZQ , Liu YY et al. Requirement of Galphai1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3KAKT-mTORC1 activation. J Invest Dermatol 2015; 135: 181- 191.
|
/
〈 | 〉 |