Protein & Cell >

2022 , Vol. 13 >Issue 12: 954 - 960

DOI: https://doi.org/10.1007/s13238-022-00914-6

LETTER

FTO stabilizes MIS12 and counteracts senescence

  • Sheng Zhang 1,2,3 ,
  • Zeming Wu 2,4,5 ,
  • Yue Shi 6,7 ,
  • Si Wang 8,9,10 ,
  • Jie Ren 3,4,6,7,11 ,
  • Zihui Yu 3,6,7 ,
  • Daoyuan Huang 8 ,
  • Kaowen Yan 2,4,5 ,
  • Yifang He 2,3,4,5 ,
  • Xiaoqian Liu 4,5,12 ,
  • Qianzhao Ji 2,3 ,
  • Beibei Liu 6,7 ,
  • Zunpeng Liu 3,12 ,
  • Jing Qu 3,4,5,12 ,
  • Guang-Hui Liu , 2,3,4,5,8,9 ,
  • Weimin Ci , 3,4,6,7 ,
  • Xiaoqun Wang , 1,3,4,13 ,
  • Weiqi Zhang , 3,4,6,7
Expand
  • 1. State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 2. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 3. University of Chinese Academy of Sciences, Beijing 100049, China
  • 4. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 5. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
  • 6. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
  • 7. China National Center for Bioinformation, Beijing 100101, China
  • 8. Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 9. Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • 10. Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing 400062, China
  • 11. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China
  • 12. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 13. Beijing Institute for Brain Disorders, Beijing 100069, China

Accepted date: 22 Feb 2022

Published date: 15 Dec 2022

Copyright

2022 The Author(s) 2022
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Cite this article

Sheng Zhang , Zeming Wu , Yue Shi , Si Wang , Jie Ren , Zihui Yu , Daoyuan Huang , Kaowen Yan , Yifang He , Xiaoqian Liu , Qianzhao Ji , Beibei Liu , Zunpeng Liu , Jing Qu , Guang-Hui Liu , Weimin Ci , Xiaoqun Wang , Weiqi Zhang . FTO stabilizes MIS12 and counteracts senescence[J]. Protein & Cell, 2022 , 13(12) : 954 -960 . DOI: 10.1007/s13238-022-00914-6

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Abe-KanohN, Kunisue N, MyojinT, ChinoA, Munemasa S, MurataY, SatohA, MoriyaH, NakamuraY (2019) Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12. Sci Rep 9:8866

DOI

2
BiC, WangL, YuanB, Zhou X, LiY, WangS, PangY, GaoX, HuangY, LiM (2020) Long-read individual-molecule sequencing reveals CRISPR-induced genetic heterogeneity in human ESCs. Genome Biol 21:213

DOI

3
DengK, ZhangZ, RenC, LiangY, GaoX, FanY, WangF (2021) FTO regulates myoblast proliferation by controlling CCND1 expression in an m(6)A-YTHDF2-dependent manner. Exp Cell Res 401:112524

DOI

4
FischerJ, KochL, EmmerlingC, Vierkotten J, PetersT, BrüningJC, Rüther U (2009) Inactivation of the Fto gene protects from obesity. Nature 458:894–898

DOI

5
HuangH, WengH, ChenJ (2020) m(6)A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer. Cancer Cell 37:270–288

DOI

6
JiaG, FuY, ZhaoX, Dai Q, ZhengG, YangY, YiC, LindahlT, Pan T, YangYG et al (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7:885–887

DOI

7
JiangZX, WangYN, LiZY, DaiZH, HeY, ChuK, GuJY, JiYX, SunNX, Yang F et al (2021) The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging. Cell Death Dis 12:744

DOI

8
LiL, ZangL, ZhangF, Chen J, ShenH, ShuL, LiangF, Feng C, ChenD, TaoH et al (2017) Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. Hum Mol Genet 26:2398–2411

DOI

9
LiW, ZouZ, CaiY, YangK, WangS, Liu Z, GengL, ChuQ, JiZ, ChanP et al (2022) Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell.

DOI

10
ShanH, GengL, JiangX, Song M, WangJ, LiuZ, ZhuoX, WuZ, HuJ, JiZ et al (2021) Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells. Protein Cell.

DOI

11
SunH, LiK, ZhangX, Liu J, ZhangM, MengH, YiC (2021) m(6)Amseq reveals the dynamic m(6)Am methylation in the human transcriptome. Nat Commun 12:4778

DOI

12
TaoB, HuangX, ShiJ, LiuJ, LiS, XuC, ZhongJ, Wan L, FengB, LiB (2020) FTO interacts with FOXO3a to enhance its transcriptional activity and inhibits aggression in gliomas. Signal Transduct Target Ther 5:130

DOI

13
WeiJ, LiuF, LuZ, FeiQ, AiY, HePC, ShiH, CuiX, SuR, Klungland A et al (2018) Differential m(6)A, m(6)A(m), and m(1)A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol Cell 71:973–985.e975

DOI

14
WeiC, LuoQ, WangB, Long Y, ZhangM, ShanW, YuX, XuY, QianP, HuangH (2021) Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing. Stem Cell Res 53:102362

DOI

15
WuZ, ShiY, LuM, SongM, YuZ, WangJ, WangS, Ren J, YangYG, LiuGH et al (2020) METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA. Nucleic Acids Res 48:11083–11096

DOI

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