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FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

  • Jinghui Lei 1 ,
  • Si Wang 1,2,5 ,
  • Wang Kang 4,6 ,
  • Qun Chu 3 ,
  • Zunpeng Liu 3,6 ,
  • Liang Sun 7 ,
  • Yun Ji 2,5,6 ,
  • Concepcion Rodriguez Esteban 9 ,
  • Yan Yao 8 ,
  • Juan Carlos Izpisua Belmonte 9 ,
  • Piu Chan 1 ,
  • Guang-Hui Liu , 1,2,5,6 ,
  • Weiqi Zhang , 4,5,6 ,
  • Moshi Song , 2,5 ,
  • Jing Qu , 3,5,6
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  • 1. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • 2. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 3. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
  • 4. Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
  • 5. Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
  • 6. University of Chinese Academy of Sciences, Beijing 100049, China
  • 7. The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
  • 8. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
  • 9. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla 92037, USA

Published date: 15 Feb 2021

Copyright

2020 The Author(s) 2020

Cite this article

Jinghui Lei , Si Wang , Wang Kang , Qun Chu , Zunpeng Liu , Liang Sun , Yun Ji , Concepcion Rodriguez Esteban , Yan Yao , Juan Carlos Izpisua Belmonte , Piu Chan , Guang-Hui Liu , Weiqi Zhang , Moshi Song , Jing Qu . FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction[J]. Protein & Cell, 2021 , 12(2) : 145 -151 . DOI: 10.1007/s13238-020-00779-7

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