Protein & Cell >

2021 , Vol. 12 >Issue 6: 493 - 501

DOI: https://doi.org/10.1007/s13238-020-00717-7

LETTER

Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

  • Zhaomeng Cui 1 ,
  • Yang Liu 1,2 ,
  • Wei Wan 3 ,
  • Yuyan Xu 1 ,
  • Yehui Hu 4 ,
  • Meng Ding 1,2 ,
  • Xin Dou 1,2 ,
  • Ruina Wang 1 ,
  • Hailing Li 5 ,
  • Yongmei Meng 6 ,
  • Wei Li 7 ,
  • Wei Jiang 1 ,
  • Zengxia Li 1 ,
  • Yiming Li 8 ,
  • Minjia Tan 3 ,
  • Dengke K. Ma 9 ,
  • Yu Ding 4 ,
  • Jun O. Liu 10 ,
  • Cheng Luo , 3 ,
  • Biao Yu , 7 ,
  • Qiqun Tang , 1,2 ,
  • Yongjun Dang , 1
Expand
  • 1. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200030, China
  • 2. Institute of Stem Cell Research and Regenerative Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai 200030, China
  • 3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 4. Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China
  • 5. Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
  • 6. College of Traditional Mongolian Medicine, Inner Mongolia Medical University, Mongolia 010110, China
  • 7. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • 8. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China
  • 9. Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA
  • 10. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Published date: 15 Jun 2021

Copyright

2020 The Author(s) 2020
Fold

Cite this article

Zhaomeng Cui , Yang Liu , Wei Wan , Yuyan Xu , Yehui Hu , Meng Ding , Xin Dou , Ruina Wang , Hailing Li , Yongmei Meng , Wei Li , Wei Jiang , Zengxia Li , Yiming Li , Minjia Tan , Dengke K. Ma , Yu Ding , Jun O. Liu , Cheng Luo , Biao Yu , Qiqun Tang , Yongjun Dang . Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes[J]. Protein & Cell, 2021 , 12(6) : 493 -501 . DOI: 10.1007/s13238-020-00717-7

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Cho S, Lee YH, Park H, Ryoo K, Kang K, Park J, Eom SJ, Kim MJ, Chang TS, Choi SY (2001) Glutathione S-transferase Mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem 276:12749–12755

DOI

2
Dorion S, Lambert H, Landry J (2002) Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem 277:30792–30797

DOI

3
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X (2015) Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue. Diab. Metab Res Rev 31:433–452

DOI

4
Kajimura S, Spiegelman Bruce M, Seale P (2015) Brown and beige fat: physiological roles beyond heat generation. Cell Metab 22:546–559

DOI

5
Lu P, Zhang FC, Qian SW, Li X, Cui ZM, Dang YJ, Tang QQ (2016) Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res 26:1169–1172

DOI

6
Ma XR, Xu LY, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E (2015) Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis. Cell Metab 22:695–708

DOI

7
Mary Schultz SD, Tew Kenneth D (1997) Inhibitors of glutathione S-transferases as therapeutic agents. Adv Drug Deliv Rev 26:91–104

DOI

8
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712–716

DOI

9
Nowack J, Arnold GS, Ruf T (2017) Muscle non-shivering thermogenesis and its role in the evolution of endothermy. Front Physiol 8:889

DOI

10
Ohno H, Shinoda K, Spiegelman BM, Kajimura S (2012) PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15:395–404

DOI

11
Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK (2018) Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metab 27:1121–1137

DOI

12
Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J (2014) Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun 5:5493

DOI

13
Zhou Y, Li W, Wang M, Zhang X, Zhang H, Tong X, Xiao Y (2016) Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics. Mol BioSyst 13:83–91

DOI

Options
Outlines

/

〈 〉