Protein & Cell >

2015 , Vol. 6 >Issue 3: 157 - 159

DOI: https://doi.org/10.1007/s13238-015-0137-5

PERSPECTIVE

CRISPR/Cas9 and TALE: beyond cut and paste

  • Liping Deng 1 ,
  • Ruotong Ren 1 ,
  • Jun Wu 2 ,
  • Keiichiro Suzuki 2 ,
  • Juan Carlos Izpisua Belmote , 2 ,
  • Guang-Hui Liu , 1,3,4
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  • 1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 2. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
  • 3. Beijing Institute for Brain Disorders, Beijing 100069, China
  • 4. Center for Molecular and Translational Medicine, CMTM, Beijing 100101, China

Published date: 01 Apr 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

Key words： TALE; CRISPR/Cas9; genome editing; gene expression; transcription regulation

Cite this article

Liping Deng , Ruotong Ren , Jun Wu , Keiichiro Suzuki , Juan Carlos Izpisua Belmote , Guang-Hui Liu . CRISPR/Cas9 and TALE: beyond cut and paste[J]. Protein & Cell, 2015 , 6(3) : 157 -159 . DOI: 10.1007/s13238-015-0137-5

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