Protein & Cell >

2014 , Vol. 5 >Issue 9: 704 - 713

DOI: https://doi.org/10.1007/s13238-014-0070-z

RESEARCH ARTICLE

USP33, a new player in lung cancer, mediates Slit-Robo signaling

  • Pushuai Wen 1,5,6 ,
  • Ruirui Kong 1 ,
  • Jianghong Liu 1 ,
  • Li Zhu 1 ,
  • Xiaoping Chen 2 ,
  • Xiaofei Li 3 ,
  • Yongzhan Nie 4 ,
  • Kaichun Wu 4 ,
  • Jane Y. Wu , 1,2
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  • 1. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 2. Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL 60611, USA
  • 3. Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
  • 4. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China
  • 5. University of Chinese Academy of Sciences, Beijing 100049, China
  • 6. Department of Pathophysiology, Liaoning Medical University, Jinzhou 121001, China

Received date: 19 Mar 2014

Accepted date: 09 Apr 2014

Published date: 25 Sep 2014

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role ofUSP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1inlungcancer cells, providing apreviouslyunknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.

Key words： USP33; Slit; Robo; lung cancer; Slit-Robo signaling; tumor suppressor; prognostic marker

Cite this article

Pushuai Wen , Ruirui Kong , Jianghong Liu , Li Zhu , Xiaoping Chen , Xiaofei Li , Yongzhan Nie , Kaichun Wu , Jane Y. Wu . USP33, a new player in lung cancer, mediates Slit-Robo signaling[J]. Protein & Cell, 2014 , 5(9) : 704 -713 . DOI: 10.1007/s13238-014-0070-z

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