Brain assembloid: a human model for neural circuits research

  • Shanshan Wu 1,2,3 ,
  • Da Wang 1,2,3 ,
  • Yan Liu , 1,2,3
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  • 1. Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing 211100, China
  • 2. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211100, China
  • 3. Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211100, China
yanliu@njmu.edu.cn

Received date: 15 Jun 2023

Accepted date: 14 Aug 2023

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

Cite this article

Shanshan Wu , Da Wang , Yan Liu . Brain assembloid: a human model for neural circuits research[J]. Life Medicine, 2023 , 2(5) : 1 . DOI: 10.1093/lifemedi/lnad031

1
BireyF, Andersen J, MakinsonCD, et al. Assembly of functionally integrated human forebrain spheroids. Nature 2017;545:54–9.

DOI

2
PaşcaSP, Arlotta P, BateupHS, et al. A nomenclature consensus for nervous system organoids and assembloids. Nature 2022;609:907–10.

DOI

3
XiangY, TanakaY, CakirB, et al. hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids. Cell Stem Cell 2019;24:487–497.e7.

DOI

4
BireyF, LiM-Y, GordonA, et al. Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome. Cell Stem Cell 2022;29:248–264.e7.

DOI

5
AndersenJ, RevahO, MiuraY, et al. Generation of functional human 3D cortico-motor assembloids. Cell 2020;183:1913–1929.e26.

DOI

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