Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

Abstract

There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.

Keywords

gastric cancer / vitamin D / vitamin D receptor / gene-environment interaction

References

[1] Jung KW, Won YJ, Oh CM, Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2014[J]. Cancer Res Treat, 2017, 49(2): 292–305

[2] Karimi P, Islami F, Anandasabapathy S, Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention[J]. Cancer Epidemiol Biomarkers Prev, 2014, 23(5): 700–713

[3] Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence[J]. Gastric Cancer, 2007, 10(2): 75–83

[4] Correa P, Shiao YH. Phenotypic and genotypic events in gastric carcinogenesis[J]. Cancer Res, 1994, 54(S7): 1941s–1943s

[5] Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D[J]. Annu Rev Pharmacol Toxicol, 2011, 51: 311–336.

[6] Park Y, Kim J. Association of dietary vitamin d and calcium with genetic polymorphisms in colorectal neoplasia[J]. J Cancer Prev, 2015, 20(2): 97–105

[7] Touvier M, Chan DS, Lau R, Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk[J]. Cancer Epidemiol Biomarkers Prev, 2011, 20(5): 1003–1016

[8] Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis[J]. Br J Cancer, 2014, 110(11): 2772–2784

[9] Feldman D, Krishnan AV, Swami S, The role of vitamin D in reducing cancer risk and progression[J]. Nat Rev Cancer, 2014, 14(5): 342–357

[10] McCullough ML, Bostick RM, Mayo TL. Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer[J]. Annu Rev Nutr, 2009, 29: 111–132.

[11] Li M, Li L, Zhang L, 1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21[J]. Life Sci, 2017, 179: 88–97.

[12] Eom SY, Yim DH, Zhang Y, Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean[J]. Cancer Causes Control, 2013, 24(11): 1963–1972

[13] Eom SY, Hong SM, Yim DH, Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans[J]. Cancer Med, 2016, 5(11): 3236–3335

[14] Kim M, Lee S, Ahn Y. Reproducibility and validity of a self-administered semiquantitative food frequency questionnaire among middle-aged men in Seoul[J]. Korean J Community Nutr, 1996, 1(3): 376–394.

[15] Standard food composition table[M]. Korea: Gyo Moonsa, 2012.

[16] Khayatzadeh S, Feizi A, Saneei P, Vitamin D intake, serum Vitamin D levels, and risk of gastric cancer: A systematic review and meta-analysis[J]. J Res Med Sci, 2015, 20(8): 790–796

[17] Du C, Yang S, Zhao X, Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis[J]. Oncotarget, 2017, 8(17): 29474–29486

[18] Vyas N, Companioni RC, Tiba M, Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis[J]. World J Gastrointest Oncol, 2016, 8(9): 688–694

[19] Gandini S, Boniol M, Haukka J, Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma[J]. Int J Cancer, 2011, 128(6): 1414–1424

[20] Lips P. Which circulating level of 25-hydroxyvitamin D is appropriate?[J]. J Steroid Biochem Mol Biol, 2004, 89-90(1-5): 611–614

[21] Helzlsouer KJ. Overview of the cohort consortium vitamin d pooling project of rarer cancers[J]. Am J Epidemiol, 2010, 172(1): 4–9

[22] Cong L, Wang WB, Liu Q, Foki polymorphism of the vitamin d receptor gene is associated with susceptibility to gastric cancer: a case-control study[J]. Tohoku J Exp Med, 2015, 236(3): 219–224

[23] Budhathoki S, Yamaji T, Iwasaki M, Vitamin D receptor gene polymorphism and the risk of colorectal cancer: a nested case-control study[J]. PLoS One, 2016, 11(10): e0164648

[24] Ashmore JH, Gallagher CJ, Lesko SM, No association between vitamin D intake, VDR polymorphisms, and colorectal cancer in a population-based case-control study[J]. Cancer Epidemiol Biomarkers Prev, 2015, 24(10): 1635–1637

[25] Zhou R, Tardivel A, Thorens B, Thioredoxin-interacting protein links oxidative stress to inflammasome activation[J]. Nat Immunol, 2010, 11(2): 136–140

[26] Kwon HJ, Won YS, Nam KT, Vitamin D₃ upregulated protein 1 deficiency promotes N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric carcinogenesis in mice[J]. Gut, 2012, 61(1): 53–63

[27] Ikarashi M, Takahashi Y, Ishii Y, Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease[J]. Anticancer Res, 2002, 22(6C): 4045–4048

[28] Ock SM, Hwang SS, Lee JS, Dietary supplement use by South Korean adults: Data from the national complementary and alternative medicine use survey (NCAMUS) in 2006[J]. Nutr Res Pract, 2010, 4(1): 69–74

Acknowledgments

This work was supported by the National Research Foundation of Korea Grant, funded by the Korean Government (Ministry of Education, Science and Technology) [NRF-355-2010-1-E00026 and 2012R1-A1A2044765].

RIGHTS & PERMISSIONS

2018 2018 by the Journal of Biomedical Research.