Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats

Haiyu Guo, Young-Hwan Ban, Yeseul Cha, Tae-Su Kim, Sung-Pyo Lee, Eun Suk An, Jieun Choi, Da Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi, Yun-Bae Kim

PDF(334 KB)
PDF(334 KB)
Journal of Biomedical Research ›› 2017, Vol. 31 ›› Issue (2) : 122-129. DOI: 10.7555/JBR.31.20160095
Original Article

Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats

Author information +
History +

Abstract

Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases, the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated. Sprague-Dawley rats were fed a diet containing the oils or trans-fat, and then body weights, blood lipids, and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion (MCAO) were analyzed. All the oils and trans-fat, except perilla oil, significantly increased body fats and body weight gain. Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides, respectively, while perilla oil decreased both cholesterols and triglycerides. Perilla oil not only attenuated cerebral infarction, but also restored locomotor activity and rota-rod performances of MCAO rats. It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.

Keywords

plant oil / trans-fat / blood lipid / body fat / ischemic stroke / physical activity

Cite this article

Download citation ▾
Haiyu Guo, Young-Hwan Ban, Yeseul Cha, Tae-Su Kim, Sung-Pyo Lee, Eun Suk An, Jieun Choi, Da Woom Seo, Jung-Min Yon, Ehn-Kyoung Choi, Yun-Bae Kim. Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats. Journal of Biomedical Research, 2017, 31(2): 122‒129 https://doi.org/10.7555/JBR.31.20160095

References

[1]
Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study[J]. Lancet, 1997, 349(9063): 1436–1442
Pubmed
[2]
Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke[J]. J Neuroimmunol, 2007, 184(1-2): 53–68
Pubmed
[3]
Sims NR, Muyderman H. Mitochondria, oxidative metabolism and cell death in stroke[J]. Biochim Biophys Acta, 2010, 1802(1): 80–91
Pubmed
[4]
Huh KB. The present status of nutrition-related diseases and its countermeasures[J]. Korean J Nutr, 1990, 23(3): 197–207.
[5]
Lee HK. Pattern of disease incidence and nutrition in Korea[J]. Korean J Nutr, 1996, 29(4): 381–383.
[6]
Spady DK, Woollett LA, Dietschy JM. Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids[J]. Annu Rev Nutr, 1993, 13: 355–381
Pubmed
[7]
Natio HK. Atherogenesis: current topics on etiology and risk factors[J]. Clin Chem, 1995, 41: 132–133.
[8]
Keys A. Coronary heart disease in seven countries[J]. 1970. Nutrition, 1997, 13(3): 250–252., discussion 249, 253
Pubmed
[9]
Kannel WB, Castelli WP, Gordon T, Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study[J]. Ann Intern Med, 1971, 74(1): 1–12
Pubmed
[10]
Jialal I, Devaraj S. The role of oxidized low density lipoprotein in atherogenesis[J]. J Nutr, 1996, 126(4 Suppl): 1053S–1057S
Pubmed
[11]
Glass CK, Witztum JL. Atherosclerosis. the road ahead[J]. Cell, 2001, 104(4): 503–516
Pubmed
[12]
Kim HK, Choi S, Choi H. Suppression of hepatic fatty acid synthase by feeding α-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats[J]. J Nutr Biochem, 2004, 15(8): 485–492
Pubmed
[13]
Huang MZ, Watanabe S, Kobayashi T, Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats[J]. Lipids, 1997, 32(7): 745–751
Pubmed
[14]
Okuyama H, Yamada K, Miyazawa D, Dietary lipids impacts on healthy ageing[J]. Lipids, 2007, 42(9): 821–825
Pubmed
[15]
Lanzmann-Petithory D. Alpha-linolenic acid and cardiovascular diseases[J]. J Nutr Health Aging, 2001, 5(3): 179–183
Pubmed
[16]
Heemskerk JW, Vossen RC, van Dam-Mieras MC. Polyunsaturated fatty acids and function of platelets and endothelial cells[J]. Curr Opin Lipidol, 1996, 7(1): 24–29
Pubmed
[17]
Vanschoonbeek K, de Maat MP, Heemskerk JW. Fish oil consumption and reduction of arterial disease[J]. J Nutr, 2003, 133(3): 657–660
Pubmed
[18]
De Caterina R, Cybulsky MA, Clinton SK, Omega-3 fatty acids and endothelial leukocyte adhesion molecules[J]. Prostaglandins Leukot Essent Fatty Acids, 1995, 52(2-3): 191–195
Pubmed
[19]
Zhang L, Geng Y, Yin M, Low ω-6/ω-3 polyunsaturated fatty acid ratios reduce hepatic C-reactive protein expression in apolipoprotein E-null mice[J]. Nutrition, 2010, 26(7-8): 829–834
Pubmed
[20]
Griffin MD, Sanders TA, Davies IG, Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study[J]. Am J Clin Nutr, 2006, 84(6): 1290–1298
Pubmed
[21]
de Lorgeril M, Renaud S, Mamelle N, Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease[J]. Lancet, 1994, 343(8911): 1454–1459
Pubmed
[22]
Jang JY, Kim TS, Cai J, Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation[J]. Lab Anim Res, 2014, 30(1): 21–27
Pubmed
[23]
Cha Y, Jang JY, Ban YH, Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet[J]. Lab Anim Res, 2016, 32(3): 171–179.
[24]
Huang MZ, Naito Y, Watanabe S, Effect of rapeseed and dietary oils on the mean survival time of stroke-prone spontaneously hypertensive rats[J]. Biol Pharm Bull, 1996, 19(4): 554–557
Pubmed
[25]
Ratnayake S, Lewandowski P. Rapid bioassay-guided screening of toxic substances in vegetable oils that shorten the life of SHRSP rats[J]. Lipids Health Dis, 2010, 9: 13
Pubmed
[26]
Cai J, Jang JY, Kim J, Comparative effects of plant oils on the cerebral hemorrhage in stroke-prone spontaneously hypertensive rats[J]. Nutr Neurosci, 2016, 19(7): 318–326
Pubmed
[27]
Choi BI, Park D, Lee SH, Neurobehavioural deficits correlate with the cerebral infarction volume of stroke animals: a comparative study on ischaemia-reperfusion and photothrombosis models[J]. Environ Toxicol Pharmacol, 2012, 33(1): 60–69
Pubmed
[28]
Longa EZ, Weinstein PR, Carlson S, Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989, 20(1): 84–91
Pubmed
[29]
Park D, Joo SS, Lee HJ, Microtubule-associated protein 2, an early blood marker of ischemic brain injury[J]. J Neurosci Res, 2012, 90(2): 461–467
Pubmed
[30]
Park D, Joo SS, Kim TK, Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals[J]. Cell Transplant, 2012, 21(1): 365–371
Pubmed
[31]
Park D, Lee HJ, Joo SS, Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction[J]. Exp Neurol, 2012, 234(2): 521–526
Pubmed
[32]
Park D, Yang YH, Bae DK, Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase[J]. Neurobiol Aging, 2013, 34(11): 2639–2646
Pubmed
[33]
Shen J, Hafeez A, Stevenson J, Omega-3 fatty acid supplement prevents development of intracranial atherosclerosis[J]. Neuroscience, 2016, 334: 226–235.
Pubmed
[34]
Wei M, Xiong P, Zhang L, Perilla oil and exercise decrease expressions of tumor necrosis factor-α, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia[J]. J Tradit Chin Med, 2013, 33(2): 170–175
Pubmed
[35]
Pirillo A, Catapano AL. Update on the management of severe hypertriglyceridemia—focus on free fatty acid forms of omega-3[J]. Drug Des Devel Ther, 2015, 9: 2129–2137
Pubmed
[36]
Zhang L, Geng Y, Xiao N, High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1[J]. J Atheroscler Thromb, 2009, 16(4): 463–471
Pubmed
[37]
Eussen SR, Geleijnse JM, Giltay EJ, Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction[J]. Eur Heart J, 2012, 33(13): 1582–1588
Pubmed
[38]
Endres S, Ghorbani R, Kelley VE, The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells[J]. N Engl J Med, 1989, 320(5): 265–271
Pubmed
[39]
Machado RM, Nakandakare ER, Quintao EC, Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids[J]. Atherosclerosis, 2012, 224(1): 66–74
Pubmed
[40]
Papazzo A, Conlan X, Lexis L, The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats[J]. Lipids Health Dis, 2011, 10: 180
Pubmed
[41]
Shimokawa T, Moriuchi A, Hori T, Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats[J]. Life Sci, 1988, 43(25): 2067–2075
Pubmed
[42]
Shimizu T, Igarashi J, Ohtuka Y, Effects of n-3 polyunsaturated fatty acids and vitamin E on colonic mucosal leukotriene generation, lipid peroxidation, and microcirculation in rats with experimental colitis[J]. Digestion, 2001, 63(1): 49–54
Pubmed
[43]
Zhao G, Zang SY, Jiang ZH, Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model[J]. J Nutr Biochem, 2011, 22(10): 929–936
Pubmed
[44]
Qiao H, Dong L, Zhang X, Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl-2 and claudin-5, down-regulated MDA and Bax expression[J]. Neurochem Res, 2012, 37(9): 2014–2024
Pubmed
[45]
Wu R, Ma F, Zhang L, Simultaneous determination of phenolic compounds in sesame oil using LC-MS/MS combined with magnetic carboxylated multi-walled carbon nanotubes[J]. Food Chem, 2016, 204: 334–342
Pubmed
[46]
Yim JE, Choue RW, Kim YS. Effects of dietary counceling and HMG-CoA reductase inhibitor treatment on serum lipid levels in hyperlipidemic patients[J]. Korean Nutr Soc, 1998, 8(1): 61–76.
[47]
Park D, Kyung J, Kim D, Anti-hypercholesterolemic and anti-atherosclerotic effects of polarized-light therapy in rabbits fed a high-cholesterol diet[J]. Lab Anim Res, 2012, 28(1): 39–46
Pubmed
[48]
Blaha MJ, Bansal S, Rouf R, A practical "ABCDE" approach to the metabolic syndrome[J]. Mayo Clin Proc, 2008, 83(8): 932–941
Pubmed

Acknowledgments

This work was supported by the "Food Functionality Evaluation Program" under the Ministry of Agriculture, Food and Rural Affairs and partly Korea Food Research Institute (G2015).

RIGHTS & PERMISSIONS

2017 2017 by the Journal of Biomedical Research. All rights reserved
PDF(334 KB)

Accesses

Citations

Detail

Sections
Recommended

/