Nanoliposome: As a smart nanocarrier in transdermal drug delivery system

Abstract

In the current advancement of drug delivery systems, nanoliposome vesicles act as a modernized technology for the encapsulation of bioactive agents. The prerequisite to expand biocompatible, structured, patient compliance, and guarded treatments in the biomedical sector is gaining distinctive recognition for employing the field of nanotechnology as capable medium to design new drug delivery systems. The liberty of this review is to initiate the concept of nanoliposomes and also elaborate on a few facets and mechanisms of nanoliposomes at the transdermal site. The enormous list of bioactive materials can be incorporated into nanoliposomes, ranging from the pharmaceuticals and cosmetics industry. The prototypical liposomes have inadequate possibility as a carrier for drug delivery via the skin because they do not penetrate the deeper layer of the skin. Only designed liposomes have the capacity to achieve enhanced delivery. It has unusual properties like biodegradability, biocompatibility, and nano size. The exclusive characteristics of nanoliposomes are their ability to solubilize and sectionalize both hydrophilic and hydrophobic bioactive agents. It intensifies the performance of bioactive agent by enhancing their solubility and bioavailability. High-quality phospholipids, the cornerstone of nanoliposomal lipid bilayer are the key components. This review article intends to provide an overview of liposomes and nanoliposomes their properties, preparation methods, and evaluation parameters. Also, it explains various applications of nanoliposomes in nanotherapy including diagnostics, specifically cancer, cosmetics, and nutraceuticals.

Keywords

Nanoliposome / Skin permeability / Nanocarrier / Fabrication strategies / Transdermal drug delivery system / Future prospects

References

[1] Matole V, Shegaonkar A, Kumbhar S, Thorat Y, Hosmani A. Need of liposomes as A novel drug delivery system. Res J Pharm Dosage Forms Technol. 2020;12(4):285–294.

[2] Bhandari AK, Dua JS, Rana AC. Liposome: methods of preparation and applications. Int J Pharmaceut Sci Res. 2012;3(2):14–20.

[3] Nikam NR, Patil PR, Vakhariya RR, Magdum CS. Liposomes: a novel drug delivery system: an overview. Asian J Pharm Sci. 2020;10(1):23–28.

[4] Dua JS, Rana AC, Bhandari AK. Liposome: methods of preparation and applications. Int J Pharmaceut Sci Res. 2012;3(2):14–20.

[5] Chauhan SB, Gupta V. Recent advances in liposome. Res J Pharm Technol. 2020;13(4):2051–2056.

[6] Mulla TS, Thorat MS, Rayate Y, Nitalikar M. Liposome as a drug carrier. Asian J Pharm Sci. 2019;9(2):141–147.

[7] Xiao WU, Richard HG. Applications of nanoparticles in topical drug delivery and in cosmetics. J Drug Deliv Sci Technol. 2009;19(6):371–384.

[8] Mali AD, Bathe RS. An updated review on liposome drug delivery system. Asian J Pharm Sci. 2015;5(3):151–157.

[9] Chavan MB, Tarade DP, Jain RS. A short review on liposome. Asian Journal of Research in Pharmaceutical Sciences. 2022;12(1), 49-1.

[10] Pastore MN, Kalia YN, Horstmann M, Roberts MS. Transdermal patches: history, development and pharmacology. Br J Pharmacol. 2015;172(9):2179–2209.

[11] Maurya P, Singh S, Saraf SA. Inhalable hybrid nanocarriers for respiratory disorders. Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. 2020:281–302.

[12] Uchechi O, Ogbonna JDN, Attama AA. Nanoparticles for dermal and transdermal drug delivery. Application of nanotechnology in. Drug Deliv. 2014:193–245.

[13] Pérez KMA, Castrillo JIA, Medina DI, Saldivar RP, Iqbal HMN. Insight into nanoliposomes as smart nanocarriers for greening the twenty-first century biomedical settings. Front Bioeng Biotechnol. 2020;8:1–23.

[14] Mozafari MR. Nanoliposomes: preparation and analysis, Methods. Molecular Biology. 2010 Jan;605:29–50.

[15] Jesorka A, Orwar O. Liposomes: technologies and analytical applications. Annu Rev Anal Chem. 2008;1(1):801–832.

[16] Nomani MS, Samy JG. Nanoliposome: an alternative approach for drug delivery system. International Journal of Advances in Pharmacy Medicine and Bioallied Sciences. 2016:1–10.

[17] Aguilar-Perez KM, Aviles-Castrillo JI, Medina DI, Saldivar RP, Hafiz MNI. Insight into nanoliposomes as smart nanocarriers for greening the twenty-first century biomedical settings. Fron bioen biotechnol. 2020;8:1–23.

[18] Ray A. Liposome in Drug delivery system. Asian Journal of Research in Pharmaceutical Sciences. 2012;2(2):41–44.

[19] Hmingthansanga V, Singh N, Banerjee S, Manickam S, Velayutham R, Natesan S. Improved topical drug delivery: role of permeation enhancers and advanced approaches. Pharmaceutics. 2022;14(2818):1–31.

[20] Zohreh F, Pedram E, Hadis D, Abolfazl A. Nanoliposomes: synthesis methods and applications in cosmetics. J Cosmet Laser Ther. 2016;18(3):174–181.

[21] Yang S, Liu C, Liu W, et al. Preparation and characterization of nanoliposomes entrapping medium-chain fatty acids and vitamin c by lyophilization. Int J Mol Sci. 2013;14:9763–9773.

[22] Patel MC, Patel HK, Suthar RM, Patel SR. Liposomes: as a topical drug delivery system. International journal of pharmaceutical and chemical sciences. 2012;1(1):1–10.

[23] Souto EB, Macedo AS, Ferreira JD, Cano A, Nska AZ, Matos CM. Elastic and ultradeformable liposomes for transdermal delivery of active pharmaceutical ingredients (APIs). Int J Mol Sci. 2021;22(9743):1–14.

[24] Hamdi Nsairat , Khater Dima , Usama Sayed , Odeh Fadwa , Abeer Al Bawab , Alshaer Walhan . Liposomes: structure, composition, types, and clinical applications. Heliyo. 2022;8:1–15.

[25] Wu X, Guy RH. Applications of nanoparticles in topical drug delivery and in cosmetics. J Drug Deliv Sci Technol. 2009;19(6):371–384.

[26] Sharma A, et al. Application of nanocarrier in drug development with special emphasis on liposomes: a review. Asian Journal of Pharmacy and Technology. 2022;12(4):320–328.

[27] Patel N, Patel C, Vachhani S, Prajapati ST, Patel CN. Recent advances in transdermal drug delivery system. Res J Pharm Dosage Forms Technol. 2010;2(2):113–119.

[28] Akbarzadeh A, Sadabady RR, Davaran S, et al. Liposome: classification, preparation, and applications. Nanoscale Res Lett. 2013;8(102):1–9.

[29] Roge AB, Sakhare RS, Bakal RL, et al. Ethosomes: novel approach in transdermal drug delivery system. Res J Pharm Dosage Forms Technol. 2020;2(1):23–27.

[30] Chorghe BR, Deshpande ST, Shah RD, Korabu SS, Motarwar SV. Transdermal drug delivery system: a review. Res J Pharm Dosage Forms Technol. 2013;5(2):65–69.

[31] Lombardo D, Kiselev MA. Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application. Pharmaceutics. 2022;14(543):1–49.

[32] Sirisha S. A review on delivery of anti-cancer drugs by smart nanocarriers: data obtained from past one decade. Res J Pharm Dosage Forms Technol. 2020;12(3):185–190.

[33] Pagar KR, Khandbahale SV. A review on novel drug delivery system: a recent trend. Asian Journal of Pharmacy and Technology. 2019;9(2):135–140.

[34] Chian M, Shokrgozar MA, Azadmanesh K, Norouzian D. Preparation, characterization, and in vitro evaluation of bleomycin containing nanoliposomes. Chem Biol Drug Des. 2016;89(4):492–497.

[35] Alur A, Iliger SR, Abbigerimath S, et al. Formulation and evaluation of topical liposomes of an antifungal drug. Unique Journal of Pharmaceutical and Biological Sciences. 2017;5(2):1–8.

[36] Nsairat H, Khater D, Sayed D, Odeh F, Bawab AA, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyo. 2022;8:1–15.

[37] Nugraheni RW, Yusuf H, Setyawan D. Design of liposomes based vaccine adjuvant system. Asian J Pharm Tech. 2018;8(4):261–263.

[38] Peng X, Yang G, Shi Y, Zhou Y, Zhang M, Li S. Box-Behnken design based statistical modelling for the extraction and physicochemical properties of pectin from sunflower heads and the comparison with commercial low methoxyl pectin. Sci Rep. 2020;10:1–10.

[39] Sun S, Li B, Yang T, et al. Preparation, and evaluation of smart nanocarrier systems for drug delivery using magnetic nanoparticle and avidin-iminobiotin system. J Nanomater. 2018:1–12.

[40] Mazumder R, Mahanti B, Majumdar S, Pal R, Chowdhury AD. Response surface method for optimization of prepared satranidazole powder layered pellets. Future J Pharmaceut Sci. 2021;7(190):1–11.

[41] Majumdar S, Mondal M, Bose A, Kar AK, Mazumder R. Fabrication, design, and in vivo investigation of mesoporous silica-based docetaxel trihydrate nanoparticles for colonic drug delivery. Bull Natl Res Cent. 2023;47(142):1–16.

[42] Yadav D, Sandeep K, Pandey D, Dutta RK. Liposomes for drug delivery. J Biotechnol Biomater. 2017;7(4):1–8.

[43] Guan Y, Zuo T, Chang M, et al. Propranolol hydrochloride-loaded liposomal gel for transdermal delivery: characterization and in vivo evaluation. Int J Pharm. 2015;487(1–2):135–141.

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